onr:"swepub:oai:DiVA.org:uu-245408"
Search: onr:"swepub:oai:DiVA.org:uu-245408" > Cyclin E1 is a stro...
- 1 of 1
- Previous record
- Next record
- To hitlist
Cyclin E1 is a strong prognostic marker for death from lymph node negative breast cancer : A population-based case-control study
-
- Lundgren, Claudia (author)
- Uppsala universitet,Experimentell och klinisk onkologi
- Ahlin, Cecilia (author)
-
- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
- show more...
- Blomqvist, Carl (author)
- show less...
- (creator_code:org_t)
- 2015
- 2015
- English.
- In: Acta Oncologica. - 0284-186X .- 1651-226X. ; 54:4, s. 538-544
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background. A large proportion of women with lymph node negative breast cancer treated with systemic adjuvant treatment do not benefit from such therapy since the patient is already cured by local treatment. Several studies have suggested that proliferation markers are strong prognostic factors in early breast cancer. Cyclins are probably the most specific markers of cell proliferation. Previously high expression of cyclin E has been associated with breast cancer recurrence.Materials and methods. In this study we investigate the prognostic value of cyclin E1 in node negative breast cancer patients. In a population-based cohort 186 women who died from breast cancer were defined as cases and 186 women alive at the corresponding time as controls. Inclusion criteria were tumour size ≤ 50 mm, no lymph node metastases and no adjuvant chemotherapy. The study was designed to detect an odds ratio of 2.5 with a power of 90% and significance level of 0.05. Cyclin E1 was determined with immunohistochemistry (IHC) on tissue microarray (TMA).Results. High expression of cyclin E1 was significantly associated with breast cancer death, in both uni- and multivariate analyses with odds ratios (OR) 2.3 [univariate, 95% confidence interval (CI) 1.5-3.6] and 2.1 (multivariate, 95% CI 1.2-3.5).Discussion. Cyclin E1 is a strong prognostic factor for breast cancer death in a population-based and node negative patient cohort and can identify high-risk patients in this group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Acta Oncologica (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lundgren, Claudi ...
- Ahlin, Cecilia
- Holmberg, Lars
- Amini, Rose-Mari ...
- Fjällskog, Marie ...
- Blomqvist, Carl
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Acta Oncologica
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
