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The locus C11orf30 increases susceptibility to poly-sensitization
- Amaral, A F S (author)
- Minelli, C (author)
- Guerra, S (author)
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- Wjst, M (author)
- Probst-Hensch, N (author)
- Pin, I (author)
- Svanes, C (author)
- Heinrich, J (author)
- Jarvis, D L (author)
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- (creator_code:org_t)
- 2014-12-24
- 2015
- English.
- In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 70:3, s. 328-333
- Journal article (peer-reviewed)
Abstract
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- A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- Amaral, A F S
- Minelli, C
- Guerra, S
- Wjst, M
- Probst-Hensch, N
- Pin, I
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- Svanes, C
- Janson, Christer
- Heinrich, J
- Jarvis, D L
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- MEDICAL AND HEALTH SCIENCES
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- Uppsala University
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