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  • Peeters, Sarah G J A (author)

A Comparative Study of the Hypoxia PET Tracers [(18)F]HX4, [(18)F]FAZA, and [(18)F]FMISO in a Preclinical Tumor Model.

  • Article/chapterEnglish2015

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  • Elsevier BV,2015
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-246182
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246182URI
  • https://doi.org/10.1016/j.ijrobp.2014.09.045DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating tumor hypoxia by using noninvasive positron emission tomography (PET). The current study compared 3 hypoxia PET tracers frequently used in the clinic, [(18)F]FMISO, [(18)F]FAZA, and [(18)F]HX4, in a preclinical tumor model. Tracer uptake was evaluated for the optimal time point for imaging, tumor-to-blood ratios (TBR), spatial reproducibility, and sensitivity to oxygen modification.METHODS AND MATERIALS: PET/computed tomography (CT) images of rhabdomyosarcoma R1-bearing WAG/Rij rats were acquired at multiple time points post injection (p.i.) with one of the hypoxia tracers. TBR values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor oxygen modifications were induced by exposure to either carbogen/nicotinamide treatment or 7% oxygen breathing.RESULTS: TBR was stabilized and maximal at 2 hours p.i. for [(18)F]FAZA (4.0 ± 0.5) and at 3 hours p.i. for [(18)F]HX4 (7.2 ± 0.7), whereas [(18)F]FMISO showed a constant increasing TBR (9.0 ± 0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both [(18)F]FMISO (R = 0.86; Dice coefficient = 0.76) and [(18)F]HX4 (R = 0.76; Dice coefficient = 0.70), whereas [(18)F]FAZA was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the hypoxic fraction resulted in enhanced mean standardized uptake values for both [(18)F]HX4 and [(18)F]FAZA upon 7% oxygen breathing. Only [(18)F]FMISO uptake was found to be reversible upon exposure to nicotinamide and carbogen.CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

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  • Zegers, Catharina M L (author)
  • Lieuwes, Natasja G (author)
  • van Elmpt, Wouter (author)
  • Eriksson, JonasVU Medical Center Amsterdam(Swepub:uu)joeri542 (author)
  • van Dongen, Guus A M S (author)
  • Dubois, Ludwig (author)
  • Lambin, Philippe (author)
  • VU Medical Center Amsterdam (creator_code:org_t)

Related titles

  • In:International journal of radiation oncology, biology, physics: Elsevier BV91:2, s. 351-91879-355X0360-3016

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