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Effect of body mass...
Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation.
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Aplenc, Richard (author)
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Zhang, Mei-Jie (author)
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Sung, Lillian (author)
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Zhu, Xiaochun (author)
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Ho, Vincent T (author)
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Cooke, Kenneth (author)
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Dvorak, Christopher (author)
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Hale, Gregory (author)
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Isola, Luis M (author)
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Lazarus, Hillard M (author)
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McCarthy, Philip L (author)
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- Olsson, Richard (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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Pulsipher, Michael (author)
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Pasquini, Marcelo C (author)
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Bunin, Nancy (author)
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(creator_code:org_t)
- American Society of Hematology, 2014
- 2014
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 123:22, s. 3504-11
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The rising incidence of pediatric obesity may significantly affect bone marrow transplantation (BMT) outcomes. We analyzed outcomes in 3687 children worldwide who received cyclophosphamide-based BMT regimens for leukemias between 1990 and 2007. Recipients were classified according to age-adjusted body mass index (BMI) percentiles as underweight (UW), at risk of UW (RUW), normal, overweight (OW), or obese (OB). Median age and race were similar in all groups. Sixty-one percent of OB children were from the United States/Canada. Three-year relapse-free and overall survival ranged from 48% to 52% (P = .54) and 55% to 58% (P = .81) across BMI groups. Three-year leukemia relapses were 33%, 33%, 29%, 25%, and 21% in the UW, RUW, normal, OW, and OB groups, respectively (P < .001). Corresponding cumulative incidences for transplant-related mortality (TRM) were 18%, 19%, 21%, 22%, and 28% (P < .01). Multivariate analysis demonstrated a decreased risk of relapse compared with normal BMI (relative risk [RR] = 0.73; P < .01) and a trend toward higher TRM (RR = 1.28; P = .014). BMI in children is not significantly associated with different survival after BMT for hematologic malignancies. Obese children experience less relapse posttransplant compared with children with normal BMI; however, this benefit is offset by excess in TRM.
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- art (subject category)
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Blood
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- By the author/editor
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Aplenc, Richard
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Zhang, Mei-Jie
-
Sung, Lillian
-
Zhu, Xiaochun
-
Ho, Vincent T
-
Cooke, Kenneth
-
show more...
-
Dvorak, Christop ...
-
Hale, Gregory
-
Isola, Luis M
-
Lazarus, Hillard ...
-
McCarthy, Philip ...
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Olsson, Richard
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Pulsipher, Micha ...
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Pasquini, Marcel ...
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Bunin, Nancy
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show less...
- Articles in the publication
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Blood
- By the university
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Uppsala University
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Karolinska Institutet