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Effect of body mass...
Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation.
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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American Society of Hematology,2014
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-246896
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246896URI
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https://doi.org/10.1182/blood-2013-03-490334DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129831070URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The rising incidence of pediatric obesity may significantly affect bone marrow transplantation (BMT) outcomes. We analyzed outcomes in 3687 children worldwide who received cyclophosphamide-based BMT regimens for leukemias between 1990 and 2007. Recipients were classified according to age-adjusted body mass index (BMI) percentiles as underweight (UW), at risk of UW (RUW), normal, overweight (OW), or obese (OB). Median age and race were similar in all groups. Sixty-one percent of OB children were from the United States/Canada. Three-year relapse-free and overall survival ranged from 48% to 52% (P = .54) and 55% to 58% (P = .81) across BMI groups. Three-year leukemia relapses were 33%, 33%, 29%, 25%, and 21% in the UW, RUW, normal, OW, and OB groups, respectively (P < .001). Corresponding cumulative incidences for transplant-related mortality (TRM) were 18%, 19%, 21%, 22%, and 28% (P < .01). Multivariate analysis demonstrated a decreased risk of relapse compared with normal BMI (relative risk [RR] = 0.73; P < .01) and a trend toward higher TRM (RR = 1.28; P = .014). BMI in children is not significantly associated with different survival after BMT for hematologic malignancies. Obese children experience less relapse posttransplant compared with children with normal BMI; however, this benefit is offset by excess in TRM.
Added entries (persons, corporate bodies, meetings, titles ...)
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Zhang, Mei-Jie
(author)
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Sung, Lillian
(author)
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Zhu, Xiaochun
(author)
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Ho, Vincent T
(author)
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Cooke, Kenneth
(author)
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Dvorak, Christopher
(author)
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Hale, Gregory
(author)
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Isola, Luis M
(author)
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Lazarus, Hillard M
(author)
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McCarthy, Philip L
(author)
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Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)riols677
(author)
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Pulsipher, Michael
(author)
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Pasquini, Marcelo C
(author)
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Bunin, Nancy
(author)
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Uppsala universitetCentrum för klinisk forskning i Sörmland (CKFD)
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology123:22, s. 3504-110006-49711528-0020
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Aplenc, Richard
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Zhang, Mei-Jie
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Sung, Lillian
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Zhu, Xiaochun
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Ho, Vincent T
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Cooke, Kenneth
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Dvorak, Christop ...
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Hale, Gregory
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Isola, Luis M
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Lazarus, Hillard ...
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McCarthy, Philip ...
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Olsson, Richard
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Pulsipher, Micha ...
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Pasquini, Marcel ...
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Bunin, Nancy
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Blood
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Uppsala University
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Karolinska Institutet