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New Cancers after A...
New Cancers after Autotransplantations for Multiple Myeloma
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Mahindra, Anuj (author)
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Raval, Girindra (author)
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Mehta, Paulette (author)
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Brazauskas, Ruta (author)
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Zhang, Mei-Jie (author)
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Zhong, Xiaobo (author)
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Bird, Jennifer M (author)
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Freytes, César O (author)
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Hale, Gregory A (author)
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Herzig, Roger (author)
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Holmberg, Leona A (author)
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Kamble, Rammurti T (author)
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Kumar, Shaji (author)
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Lazarus, Hillard M (author)
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Majhail, Navneet S (author)
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Marks, David I (author)
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Moreb, Jan S (author)
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- Olsson, Richard (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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Saber, Wael (author)
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Savani, Bipin N (author)
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Schiller, Gary J (author)
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Tay, Jason (author)
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Vogl, Dan T (author)
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Waller, Edmund K (author)
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Wiernik, Peter H (author)
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Wirk, Baldeep (author)
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Lonial, Sagar (author)
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Krishnan, Amrita Y (author)
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Dispenzieri, Angela (author)
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Brandenburg, Nancy A (author)
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Gale, Robert Peter (author)
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Hari, Parameswaran (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 21:4, s. 738-745
- Related links:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7 years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P = .0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Mahindra, Anuj
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Raval, Girindra
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Mehta, Paulette
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Brazauskas, Ruta
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Zhang, Mei-Jie
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Zhong, Xiaobo
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show more...
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Bird, Jennifer M
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Freytes, César O
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Hale, Gregory A
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Herzig, Roger
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Holmberg, Leona ...
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Kamble, Rammurti ...
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Kumar, Shaji
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Lazarus, Hillard ...
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Majhail, Navneet ...
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Marks, David I
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Moreb, Jan S
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Olsson, Richard
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Saber, Wael
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Savani, Bipin N
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Schiller, Gary J
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Tay, Jason
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Vogl, Dan T
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Waller, Edmund K
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Wiernik, Peter H
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Wirk, Baldeep
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Lonial, Sagar
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Krishnan, Amrita ...
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Dispenzieri, Ang ...
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Brandenburg, Nan ...
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Gale, Robert Pet ...
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Hari, Parameswar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Biology of blood ...
- By the university
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Uppsala University
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Karolinska Institutet