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New Cancers after A...
New Cancers after Autotransplantations for Multiple Myeloma
- Article/chapterEnglish2015
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Elsevier BV,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-246900
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246900URI
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https://doi.org/10.1016/j.bbmt.2014.12.028DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130959690URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7 years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P = .0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.
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Raval, Girindra
(author)
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Mehta, Paulette
(author)
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Brazauskas, Ruta
(author)
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Zhang, Mei-Jie
(author)
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Zhong, Xiaobo
(author)
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Bird, Jennifer M
(author)
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Freytes, César O
(author)
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Hale, Gregory A
(author)
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Herzig, Roger
(author)
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Holmberg, Leona A
(author)
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Kamble, Rammurti T
(author)
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Kumar, Shaji
(author)
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Lazarus, Hillard M
(author)
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Majhail, Navneet S
(author)
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Marks, David I
(author)
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Moreb, Jan S
(author)
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Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)riols677
(author)
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Saber, Wael
(author)
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Savani, Bipin N
(author)
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Schiller, Gary J
(author)
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Tay, Jason
(author)
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Vogl, Dan T
(author)
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Waller, Edmund K
(author)
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Wiernik, Peter H
(author)
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Wirk, Baldeep
(author)
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Lonial, Sagar
(author)
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Krishnan, Amrita Y
(author)
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Dispenzieri, Angela
(author)
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Brandenburg, Nancy A
(author)
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Gale, Robert Peter
(author)
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Hari, Parameswaran
(author)
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Uppsala universitetCentrum för klinisk forskning i Sörmland (CKFD)
(creator_code:org_t)
Related titles
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In:Biology of blood and marrow transplantation: Elsevier BV21:4, s. 738-7451083-87911523-6536
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Mahindra, Anuj
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Raval, Girindra
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Mehta, Paulette
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Brazauskas, Ruta
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Zhang, Mei-Jie
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Zhong, Xiaobo
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Bird, Jennifer M
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Freytes, César O
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Hale, Gregory A
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Herzig, Roger
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Holmberg, Leona ...
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Kamble, Rammurti ...
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Kumar, Shaji
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Lazarus, Hillard ...
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Majhail, Navneet ...
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Marks, David I
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Moreb, Jan S
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Olsson, Richard
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Saber, Wael
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Savani, Bipin N
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Schiller, Gary J
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Tay, Jason
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Vogl, Dan T
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Waller, Edmund K
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Wiernik, Peter H
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Wirk, Baldeep
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Lonial, Sagar
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Krishnan, Amrita ...
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Dispenzieri, Ang ...
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Brandenburg, Nan ...
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Gale, Robert Pet ...
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Hari, Parameswar ...
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- MEDICAL AND HEALTH SCIENCES
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and Hematology
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Biology of blood ...
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Uppsala University
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Karolinska Institutet