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Epidemiology of non...
Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia
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Qvist, Tavs (author)
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Gilljam, Marita (author)
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Jonsson, Bodil (author)
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Taylor-Robinson, David (author)
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Jensen-Fangel, Soren (author)
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Wang, Mikala (author)
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Svahn, Anita (author)
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Kotz, Karsten (author)
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- Hansson, Lennart (author)
- Lund University,Lunds universitet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Hollsing, Annika (author)
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Hansen, Christine R. (author)
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Finstad, Pal L. (author)
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Pressler, Tania (author)
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Hoiby, Niels (author)
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Katzenstein, Terese L. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993 .- 1873-5010. ; 14:1, s. 46-52
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.cysticfib...
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
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- Background: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. Methods: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. Results: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p < 0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. Conclusion: NTM are significant CF pathogens and are becoming. more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Mycobacterium abscessus
- Mycobacterium avium
- Prevalence
- Susceptibility
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Qvist, Tavs
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Gilljam, Marita
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Jonsson, Bodil
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Taylor-Robinson, ...
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Jensen-Fangel, S ...
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Wang, Mikala
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show more...
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Svahn, Anita
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Kotz, Karsten
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Hansson, Lennart
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Hollsing, Annika
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Hansen, Christin ...
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Finstad, Pal L.
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Pressler, Tania
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Hoiby, Niels
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Katzenstein, Ter ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Cysti ...
- By the university
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Uppsala University
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Lund University