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Determination of th...
Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS
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- Kjellin, Linda L. (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Dorsey, Grant (author)
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Rosenthal, Philip J. (author)
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Aweeka, Francesca (author)
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Huang, Liusheng (author)
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(creator_code:org_t)
- Future Science Ltd, 2014
- 2014
- English.
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In: Bioanalysis. - : Future Science Ltd. - 1757-6180 .- 1757-6199. ; 6:23, s. 3081-3089
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Subject headings
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- Aim: Determination of piperaquine (PQ) in pediatric plasma requires a method with a small sample volume. Results: We report a sensitive LC-MS/MS method for quantitation of PQ with only 25 mu l human plasma. Using a deuterated internal standard (PQ-d(6)), an analytical PFP column, APCI(+) as the ion source and MRM (535/288 for PQ and 541/294 for the IS) for detection, the method has a linear calibration range of 1.5-250 ng/ml with a runtime of 3.0 min per sample. The method was applied to plasma samples from children. Conclusion: The developed LC-MS/MS method is suitable for pediatric studies with small volume plasma samples collected via capillary tubes. One limitation was the performance of PFP columns varied among different brands.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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