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Acute brain lesions...
Acute brain lesions on MRI in relation to neurological outcome 6 months after cardiac arrest treated with hypothermia.
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- Wallin, Ewa (author)
- Uppsala universitet,Anestesiologi och intensivvård,Department of Surgical Sciences – Anaesthesiology & Intensive Care, Uppsala University, Uppsala, Sweden
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- Larsson, Ing-Marie (author)
- Uppsala universitet,Anestesiologi och intensivvård,Department of Surgical Sciences – Anaesthesiology & Intensive Care, Uppsala University, Uppsala, Sweden
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- Kristofferzon, Marja-Leena (author)
- Högskolan i Gävle,Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Medicin- och vårdvetenskap
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- Rubertsson, Sten (author)
- Uppsala universitet,Anestesiologi och intensivvård,Department of Surgical Sciences – Anaesthesiology & Intensive Care, Uppsala University, Uppsala, Sweden
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences – Radiology, Uppsala University, Uppsala, Sweden
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- Raininko, Raili (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences – Radiology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 96:Suppl1, s. 147-
- Related links:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aim of the study: To document the acute magnetic resonance imaging (MRI) findings on the brain in cardiac arrest (CA) patients treated with therapeutic hypothermia (TH) and their relation to patients’ neurological outcome after 6 months.Method: A prospective observational study with MRI was performed regardless the level of consciousness in 56 post-CA patients treated with TH.Results: MRI of the brain was obtained at a median of 4 days (3-13 days). At 6 months, 32/56 had survived with good neurological outcome. The MMSE was performed in 28/32 (88%) patients with a median of 28 (24-30). Acute ischemic lesions were found on diffusion-weighted MRI (DWI) in 34 (61%) patients and were more common in patients with poor outcome (p=0.006). Acute ischemic injuries affected mostly gray matter, deep or cortical and with or without involvement of the underlying white matter. Very few lesions were pure white matter lesions. Lesions in the occipital and temporal lobes, deep gray matter and cerebellum were most associated with poor outcome. Reductions in the apparent diffusion coefficient (ADC) were more common in patients with poor outcome, particularly in the occipital lobes. None of the patients with an ADC below 600x10-6 mm2/s in any region survived to 6 months.Conclusions: In visual analyses of acute MRI, extensive acute lesions were found in the cortical regions and gray matter and were associated with poor outcome. In ADC measurements, low values were associated with poor outcome. Patients with good outcome showed a minor pathological pattern mainly in the frontal and parietal lobes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- cardiac arrest
- hypothermia
- MRI
- diffusion brain acute lesions
- neurological outcome
- Medical Science
- Medicinsk vetenskap
- Anaesthesiology and Intensive Care
- Anestesiologi och intensivvård
Publication and Content Type
- vet (subject category)
- art (subject category)
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