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Assessing Improveme...
Assessing Improvement in Detection of Breast Cancer with Three-dimensional Automated Breast US in Women with Dense Breast Tissue : The Somoinsight Study
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Brem, Rachel F. (author)
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- Tabar, Laszlo (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Duffy, Stephen W. (author)
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Inciardi, Marc F. (author)
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Guingrich, Jessica A. (author)
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Hashimoto, Beverly E. (author)
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Lander, Marla R. (author)
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Lapidus, Robert L. (author)
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Peterson, Mary Kay (author)
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Rapelyea, Jocelyn A. (author)
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Roux, Susan (author)
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Schilling, Kathy J. (author)
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Shah, Biren A. (author)
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Torrente, Jessica (author)
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Wynn, Ralph T. (author)
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Miller, Dave P. (author)
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(creator_code:org_t)
- Radiological Society of North America (RSNA), 2015
- 2015
- English.
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In: Radiology. - : Radiological Society of North America (RSNA). - 0033-8419 .- 1527-1315. ; 274:3, s. 663-673
- Related links:
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https://pubs.rsna.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: To determine improvement in breast cancer detection by using supplemental three-dimensional (3D) automated breast (AB) ultrasonography (US) with screening mammography versus screening mammography alone in asymptomatic women with dense breasts. Materials and Methods: Institutional review board approval and written informed consent were obtained for this HIPAA-compliant study. The SomoInsight Study was an observational, multicenter study conducted between 2009 and 2011. A total of 15 318 women (mean age, 53.3 years +/- 10 [standard deviation]; range, 2594 years) presenting for screening mammography alone with heterogeneously (50%75%) or extremely (>75%) dense breasts were included, regardless of further risk characterization, and were followed up for 1 year. Participants underwent screening mammography alone followed by an AB US examination; results were interpreted sequentially. McNemar test was used to assess differences in cancer detection. Results: Breast cancer was diagnosed at screening in 112 women: 82 with screening mammography and an additional 30 with AB US. Addition of AB US to screening mammography yielded an additional 1.9 detected cancers per 1000 women screened (95% confidence interval [CI]: 1.2, 2.7; P < .001). Of cancers detected with screening mammography, 62.2% (51 of 82) were invasive versus 93.3% (28 of 30) of additional cancers detected with AB US (P = .001). Of the 82 cancers detected with either screening mammography alone or the combined read, 17 were detected with screening mammography alone. Of these, 64.7% (11 of 17) were ductal carcinoma in situ versus 6.7% (two of 30) of cancers detected with AB US alone. Sensitivity for the combined read increased by 26.7% (95% CI: 18.3%, 35.1%); the increase in the recall rate per 1000 women screened was 284.9 (95% CI: 278.0, 292.2; P < .001). Conclusion: Addition of AB US to screening mammography in a generalizable cohort of women with dense breasts increased the cancer detection yield of clinically important cancers, but it also increased the number of false-positive results. (C)RNSA, 2014.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- ref (subject category)
- art (subject category)
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Radiology
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- By the author/editor
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Brem, Rachel F.
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Tabar, Laszlo
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Duffy, Stephen W ...
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Inciardi, Marc F ...
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Guingrich, Jessi ...
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Hashimoto, Bever ...
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show more...
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Lander, Marla R.
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Lapidus, Robert ...
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Peterson, Mary K ...
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Rapelyea, Jocely ...
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Roux, Susan
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Schilling, Kathy ...
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Shah, Biren A.
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Torrente, Jessic ...
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Wynn, Ralph T.
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Miller, Dave P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Radiology
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Uppsala University