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Assessing Improveme...
Assessing Improvement in Detection of Breast Cancer with Three-dimensional Automated Breast US in Women with Dense Breast Tissue : The Somoinsight Study
- Article/chapterEnglish2015
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Radiological Society of North America (RSNA),2015
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LIBRIS-ID:oai:DiVA.org:uu-248445
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248445URI
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https://doi.org/10.1148/radiol.14132832DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Purpose: To determine improvement in breast cancer detection by using supplemental three-dimensional (3D) automated breast (AB) ultrasonography (US) with screening mammography versus screening mammography alone in asymptomatic women with dense breasts. Materials and Methods: Institutional review board approval and written informed consent were obtained for this HIPAA-compliant study. The SomoInsight Study was an observational, multicenter study conducted between 2009 and 2011. A total of 15 318 women (mean age, 53.3 years +/- 10 [standard deviation]; range, 2594 years) presenting for screening mammography alone with heterogeneously (50%75%) or extremely (>75%) dense breasts were included, regardless of further risk characterization, and were followed up for 1 year. Participants underwent screening mammography alone followed by an AB US examination; results were interpreted sequentially. McNemar test was used to assess differences in cancer detection. Results: Breast cancer was diagnosed at screening in 112 women: 82 with screening mammography and an additional 30 with AB US. Addition of AB US to screening mammography yielded an additional 1.9 detected cancers per 1000 women screened (95% confidence interval [CI]: 1.2, 2.7; P < .001). Of cancers detected with screening mammography, 62.2% (51 of 82) were invasive versus 93.3% (28 of 30) of additional cancers detected with AB US (P = .001). Of the 82 cancers detected with either screening mammography alone or the combined read, 17 were detected with screening mammography alone. Of these, 64.7% (11 of 17) were ductal carcinoma in situ versus 6.7% (two of 30) of cancers detected with AB US alone. Sensitivity for the combined read increased by 26.7% (95% CI: 18.3%, 35.1%); the increase in the recall rate per 1000 women screened was 284.9 (95% CI: 278.0, 292.2; P < .001). Conclusion: Addition of AB US to screening mammography in a generalizable cohort of women with dense breasts increased the cancer detection yield of clinically important cancers, but it also increased the number of false-positive results. (C)RNSA, 2014.
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Tabar, LaszloUppsala universitet,Institutionen för medicinska vetenskaper
(author)
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Duffy, Stephen W.
(author)
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Inciardi, Marc F.
(author)
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Guingrich, Jessica A.
(author)
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Hashimoto, Beverly E.
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Lander, Marla R.
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Lapidus, Robert L.
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Peterson, Mary Kay
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Rapelyea, Jocelyn A.
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Roux, Susan
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Schilling, Kathy J.
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Shah, Biren A.
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Torrente, Jessica
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Wynn, Ralph T.
(author)
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Miller, Dave P.
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Uppsala universitetInstitutionen för medicinska vetenskaper
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In:Radiology: Radiological Society of North America (RSNA)274:3, s. 663-6730033-84191527-1315
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Brem, Rachel F.
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Tabar, Laszlo
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Lander, Marla R.
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Lapidus, Robert ...
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Rapelyea, Jocely ...
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Roux, Susan
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Schilling, Kathy ...
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Shah, Biren A.
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Torrente, Jessic ...
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Wynn, Ralph T.
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Miller, Dave P.
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Radiology
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Uppsala University