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Interleukin-8 is as...
Interleukin-8 is associated with increased total mortality in women but not in men-findings from a community-based cohort of elderly
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Velasquez, Ilais Moreno (author)
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap
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- Leander, Karin (author)
- Karolinska Institutet
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Gigante, Bruna (author)
- Karolinska Institutet
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- Carlsson, Axel C. (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2014-10-10
- 2015
- English.
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In: Annals of Medicine. - : Informa UK Limited. - 0785-3890 .- 1365-2060. ; 47:1, s. 28-33
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Objective. To elucidate the association among circulating IL-8 and total mortality in a cohort of elderly, and to explore potential sex differences in the observed association. Methods. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) is a cohort of 70-year-old men and women living in Uppsala, Sweden; baseline period: 2001-2004. IL-8 serum measurements were performed in 1003 participants. Results. In total, 61 men and 40 women died during follow-up (median 7.9 years). Baseline IL-8 concentrations were higher in women than in men (P = 0.03). In a multivariable model adjusting for age, established cardiovascular risk factors, and C-reactive protein, log-transformed standard deviation increments in IL-8 levels were weakly associated with an increased risk for total mortality (hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.02 -1.23, P < 0.05) in the whole cohort. Stratified analysis revealed an association in women (HR 1.18, 95% CI 1.06-1.30, P < 0.01) but not in men (HR 0.98, 95% CI 0.76-1.26). Conclusions. A weak association between IL-8 serum levels and an increased risk for mortality was observed. The prospective data support the role of IL-8 as a biomarker of interest; yet, further studies are warranted to elucidate validity of our finding and the possibility of a sex difference.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- All-cause mortality
- community-based cohort
- cytokines
- inflammation
- interleukin-8
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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