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  • Zeisel, AmitKarolinska Institutet (author)

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-248806
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248806URI
  • https://doi.org/10.1126/science.aaa1934DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:130827044URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The mammalian cerebral cortex supports cognitive functions such as sensorimotor integration, memory, and social behaviors. Normal brain function relies on a diverse set of differentiated cell types, including neurons, glia, and vasculature. Here, we have used large-scale single-cell RNA sequencing (RNA-seq) to classify cells in the mouse somatosensory cortex and hippocampal CA1 region. We found 47 molecularly distinct subclasses, comprising all known major cell types in the cortex. We identified numerous marker genes, which allowed alignment with known cell types, morphology, and location. We found a layer I interneuron expressing Pax6 and a distinct postmitotic oligodendrocyte subclass marked by Itpr2. Across the diversity of cortical cell types, transcription factors formed a complex, layered regulatory code, suggesting a mechanism for the maintenance of adult cell type identity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Munoz-Manchado, Ana B.Karolinska Institutet (author)
  • Codeluppi, SimoneKarolinska Institutet (author)
  • Lonnerberg, PeterKarolinska Institutet (author)
  • La Manno, GioeleKarolinska Institutet (author)
  • Jureus, AnnaKarolinska Institutet (author)
  • Marques, SueliKarolinska Institutet (author)
  • Munguba, HermanyKarolinska Institutet (author)
  • He, LiqunUppsala universitet,Vaskulärbiologi(Swepub:uu)liqhe592 (author)
  • Betsholtz, ChristerKarolinska Institutet,Uppsala universitet,Vaskulärbiologi(Swepub:uu)chbet517 (author)
  • Rolny, CharlotteKarolinska Institutet (author)
  • Castelo-Branco, GoncaloKarolinska Institutet (author)
  • Hjerling-Leffler, JensKarolinska Institutet (author)
  • Linnarsson, StenKarolinska Institutet (author)
  • Karolinska InstitutetVaskulärbiologi (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)347:6226, s. 1138-11420036-80751095-9203

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