Next-Generation Sequencing Reveals a Controlled Immune Response to Zaire Ebola Virus Challenge in Cynomolgus Macaques Immunized with Vesicular Stomatitis Virus Expressing Zaire Ebola Virus Glycoprotein (VSV Delta G/EBOVgp)

Barrenäs, Fredrik (author): Uppsala universitet,Beräknings- och systembiologi

Green, Richard R. (author)

Thomas, Matthew J. (author)

Law, G. Lynn (author)

Proll, Sean C. (author)

Engelmann, Flora (author)

Messaoudi, Ilhem (author)

Marzi, Andrea (author)

Feldmann, Heinz (author)

Katze, Michael G. (author)

(creator_code:org_t)

2015
2015
English.
In: Clinical and Vaccine Immunology. - 1556-6811 .- 1556-679X. ; 22:3, s. 354-356

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

Vesicular stomatitis virus expressing Zaire Ebola virus (EBOV) glycoprotein (VSV Delta G/EBOVgp) could be used as a vaccine to meet the 2014 Ebola virus outbreak. To characterize the host response to this vaccine, we used mRNA sequencing to analyze peripheral blood mononuclear cells (PBMCs) from cynomolgus macaques after VSV Delta G/EBOVgp immunization and subsequent EBOV challenge. We found a controlled transcriptional response that transitioned to immune regulation as the EBOV was cleared. This observation supports the safety of the vaccine.

By the author/editor: Barrenäs, Fredri ...; Green, Richard R ...; Thomas, Matthew ...; Law, G. Lynn; Proll, Sean C.; Engelmann, Flora; show more...; Messaoudi, Ilhem; Marzi, Andrea; Feldmann, Heinz; Katze, Michael G ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Immunology

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