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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors

Hamann, Joerg (author)
Aust, Gabriela (author)
Arac, Demet (author)
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Engel, Felix B. (author)
Formstone, Caroline (author)
Fredriksson, Robert (author)
Uppsala universitet,Funktionell farmakologi
Hall, Randy A. (author)
Harty, Breanne L. (author)
Kirchhoff, Christiane (author)
Knapp, Barbara (author)
Krishnan, Arunkumar (author)
Uppsala universitet,Funktionell farmakologi
Liebscher, Ines (author)
Lin, Hsi-Hsien (author)
Martinelli, David C. (author)
Monk, Kelly R. (author)
Peeters, Miriam C. (author)
Piao, Xianhua (author)
Proemel, Simone (author)
Schoeneberg, Torsten (author)
Schwartz, Thue W. (author)
Singer, Kathleen (author)
Stacey, Martin (author)
Ushkaryov, Yuri A. (author)
Vallon, Mario (author)
Wolfrum, Uwe (author)
Wright, Mathew W. (author)
Xu, Lei (author)
Langenhan, Tobias (author)
Schiöth, Helgi B. (author)
Uppsala universitet,Funktionell farmakologi
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 (creator_code:org_t)
2015-02-24
2015
English.
In: Pharmacological Reviews. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0031-6997 .- 1521-0081. ; 67:2, s. 338-367
Related links:
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

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