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A unified definitio...
A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia : results of a consensus process by an international working group
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Barosi, G. (author)
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Besses, C. (author)
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- Birgegård, Gunnar, 1944- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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Briere, J. (author)
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Cervantes, F. (author)
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Finazzi, G. (author)
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Gisslinger, H. (author)
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Griesshammer, M. (author)
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Gugliotta, L. (author)
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Harrison, C. (author)
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Hasselbalch, H. (author)
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Lengfelder, E. (author)
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Reilly, J. T. (author)
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Michiels, J. J. (author)
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Barbui, T. (author)
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(creator_code:org_t)
- 2006-11-16
- 2007
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 21:2, s. 277-280
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia (ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600,000/micro l after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400,000/micro l and WBC less than 2500/micro l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU; HU-related fever.
Keyword
- essential thrombocythemia
- hydroxyurea
- analytic hierarchy process
- resistance
- intolerance
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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- By the author/editor
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Barosi, G.
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Besses, C.
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Birgegård, Gunna ...
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Briere, J.
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Cervantes, F.
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Finazzi, G.
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show more...
-
Gisslinger, H.
-
Griesshammer, M.
-
Gugliotta, L.
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Harrison, C.
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Hasselbalch, H.
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Lengfelder, E.
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Reilly, J. T.
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Michiels, J. J.
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Barbui, T.
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show less...
- Articles in the publication
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Leukemia
- By the university
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Uppsala University