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A unified definitio...
A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia : results of a consensus process by an international working group
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2006-11-16
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Springer Science and Business Media LLC,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-24970
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-24970URI
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https://doi.org/10.1038/sj.leu.2404473DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A widely accepted definition of resistance or intolerance to hydroxyurea (HU) in patients with essential thrombocythemia (ET) is lacking. An international working group (WG) was convened to develop a consensus formulation of clinically significant criteria for defining resistance/intolerance to HU in ET. To this aim, an analytic hierarchy process (AHP), a multiple-attribute decision-making technique, was used. The steps consisted of selecting the candidate criteria for defining resistance/intolerance; identifying the motivations that could influence the preference of the WG for any individual criterion; comparing the candidate criteria in a pair-wise manner; and grading them according their ability to fulfill the motivations. Every step in the model was derived by questionnaires or group discussion. The WG proposed that the definition of resistance/intolerance should require the fulfillment of at least one of the following criteria: platelet count greater than 600,000/micro l after 3 months of at least 2 g/day of HU (2.5 g/day in patients with a body weight over 80 kg); platelet count greater than 400,000/micro l and WBC less than 2500/micro l or Hb less than 10 g/dl at any dose of HU; presence of leg ulcers or other unacceptable muco-cutaneous manifestations at any dose of HU; HU-related fever.
Subject headings and genre
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essential thrombocythemia
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hydroxyurea
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analytic hierarchy process
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resistance
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intolerance
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Besses, C.
(author)
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Birgegård, Gunnar,1944-Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi(Swepub:uu)gunnarbg
(author)
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Briere, J.
(author)
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Cervantes, F.
(author)
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Finazzi, G.
(author)
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Gisslinger, H.
(author)
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Griesshammer, M.
(author)
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Gugliotta, L.
(author)
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Harrison, C.
(author)
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Hasselbalch, H.
(author)
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Lengfelder, E.
(author)
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Reilly, J. T.
(author)
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Michiels, J. J.
(author)
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Barbui, T.
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Leukemia: Springer Science and Business Media LLC21:2, s. 277-2800887-69241476-5551
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Leukemia
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Barosi, G.
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Besses, C.
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Birgegård, Gunna ...
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Briere, J.
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Cervantes, F.
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Finazzi, G.
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Gisslinger, H.
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Griesshammer, M.
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Gugliotta, L.
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Harrison, C.
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Hasselbalch, H.
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Lengfelder, E.
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Reilly, J. T.
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Michiels, J. J.
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Barbui, T.
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Leukemia
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Uppsala University