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Autoimmune and chro...
Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype
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- Smedby, Karin Ekström (author)
- Karolinska Institutet
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- Hjalgrim, Henrik (author)
- Karolinska Institutet
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- Askling, Johan (author)
- Karolinska Institutet
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Chang, Ellen T. (author)
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Gregersen, Henrik (author)
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- Porwit-MacDonald, Anna (author)
- Karolinska Institutet
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Åkerman, Måns (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Melbye, Mads (author)
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- Glimelius, Bengt (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Adami, Hans-Olov (author)
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(creator_code:org_t)
- 2006-01-04
- 2006
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 98:1, s. 51-60
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Abstract
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- BACKGROUND: Some autoimmune and chronic inflammatory disorders are associated with increased risks of non-Hodgkin lymphoma (NHL). Because different NHL subtypes develop at different stages of lymphocyte differentiation, associations of autoimmune and inflammatory disorders with specific NHL subtypes could lead to a better understanding of lymphomagenic mechanisms. METHODS: In a population-based case-control study in Denmark and Sweden, 3055 NHL patients and 3187 matched control subjects were asked about their history of autoimmune and chronic inflammatory disorders, markers of severity, and treatment. Logistic regression with adjustment for study matching factors was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for NHL overall and for NHL subtypes. RESULTS: Risks of all NHL were increased in association with rheumatoid arthritis (OR = 1.5, 95% CI = 1.1 to 1.9), primary Sjögren syndrome (OR = 6.1, 95% CI = 1.4 to 27), systemic lupus erythematosus (OR = 4.6, 95% CI = 1.0 to 22), and celiac disease (OR = 2.1, 95% CI = 1.0 to 4.8). All of these conditions were also associated with diffuse large B-cell lymphoma, and some were associated with marginal zone, lymphoplasmacytic, or T-cell lymphoma. Ever use of nonsteroidal anti-inflammatory drugs, systemic corticosteroids, and selected immunosuppressants was associated with risk of NHL in rheumatoid arthritis patients but not in subjects without rheumatoid arthritis. Also, multivariable adjustment for treatment had little impact on risk estimates. Psoriasis, sarcoidosis, and inflammatory bowel disorders were not associated with increased risk of NHL overall or of any NHL subtype. CONCLUSIONS: Our results confirm the associations between certain autoimmune disorders and risk of NHL and suggest that the associations may not be general but rather mediated through specific NHL subtypes. These NHL subtypes develop during postantigen exposure stages of lymphocyte differentiation, consistent with a role of antigenic drive in autoimmunity-related lymphomagenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Adult
- Aged
- Arthritis; Rheumatoid/*complications
- Autoantigens/immunology
- Autoimmunity
- Case-Control Studies
- Celiac Disease/*complications
- Cell Differentiation/immunology
- Chronic Disease
- Denmark
- Female
- Humans
- Inflammation/complications
- Logistic Models
- Lupus Erythematosus; Systemic/*complications
- Lymphocytes/immunology
- Lymphoma; Non-Hodgkin/*etiology/immunology
- Male
- Middle Aged
- Odds Ratio
- Risk Assessment
- Severity of Illness Index
- Sjogren's Syndrome/*complications
- Sweden
- Time Factors
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Smedby, Karin Ek ...
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Hjalgrim, Henrik
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Askling, Johan
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Chang, Ellen T.
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Gregersen, Henri ...
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Porwit-MacDonald ...
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show more...
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Sundström, Chris ...
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Åkerman, Måns
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Melbye, Mads
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Glimelius, Bengt
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Adami, Hans-Olov
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of the N ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet