EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides

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MARC

Carlsson, JörgenUppsala universitet,Medicinsk strålningsvetenskap (author)

EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides

Article/chapterEnglish2015

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2015-03-03
Walter de Gruyter GmbH,2015
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LIBRIS-ID:oai:DiVA.org:uu-251515
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251515URI
https://doi.org/10.2478/raon-2014-0015DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:130880383URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Background. There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR or HER2 for therapy of metastasized urinary bladder canter and these methods are therefore not routinely used. Targeting radionuclides to the extracellular domain of the receptors is potentially a better possibility. Methods. EGFR- and HER2-expression was analyzed for primary tumors and corresponding metastases from 72 patients using immunohistochemistry and the internationally recommended HercepTest. Intracellular mutations were not analyzed since only the receptors were considered as targets and intracellular abnormalities should have minor effect on radiation dose. Results. EGFR was positive in 71% of the primary tumors and 69% of corresponding metastases. Local and distant metastases were EGFR-positive in 75% and 66% of the cases, respectively. The expression frequency of HER2 in related lesions was slightly higher (data from previous study). The EGFR-positive tumors expressed EGFR in metastases in 86% of the cases. The co-expression of EGFR and HER2 was 57% for tumors and 53% for metastases. Only 3% and 10% of the lesions were negative for both receptors in tumors and metastases, respectively. Thus, targeting these receptors with radionuclides might be applied for most patients. Conclusions. At least one of the EGFR- or HER2-receptors was present in most cases and co-expressed in more than half the cases. It is therefore interesting to deliver radionuclides for whole-body receptor-analysis, dosimetry and therapy. This can hopefully compensate for resistance to other therapies and more patients can hopefully be treated with curative instead of palliative intention.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
EGFR
HER2
radionuclides
resistance
urinary bladder cancer metastases

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Wester, KennethUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)kennwest (author)
De La Torre, ManuelUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)manutorr (author)
Malmström, Per-UnoUppsala universitet,Urologkirurgi(Swepub:uu)perunoms (author)
Gardmark, TrulsKarolinska Institutet (author)
Uppsala universitetMedicinsk strålningsvetenskap (creator_code:org_t)

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In:Radiology and Oncology: Walter de Gruyter GmbH49:1, s. 50-581318-20991581-3207

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