Recurrence risks for schizophrenia in a Swedish national cohort

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-25201" > Recurrence risks fo...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Lichtenstein, PaulKarolinska Institutet (author)

Recurrence risks for schizophrenia in a Swedish national cohort

Article/chapterEnglish2006

Publisher, publication year, extent ...

2006
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-25201
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-25201URI
https://doi.org/10.1017/S0033291706008385DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1942349URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background. Recurrence risk estimates for schizophrenia are fundamental to our understanding of this complex disease. Widely cited estimates are from small/older samples. If these estimates are biased upwards, then the rationale for molecular genetic studies of schizophrenia may not be as solid. Method. We created a population-based, Swedish national cohort by linking two Swedish national registers into a relational database (the Swedish Hospital Discharge Register and the MultiGeneration Register). Affection was defined as the lifetime presence of at least two in-patient hospitalizations with a core schizophrenia diagnosis. Results. Merging the Swedish national registers created a population-based cohort of 7 739 202 individuals of known parentage. The lifetime prevalence of the narrow definition of schizophrenia was 0(.)407% and we estimated that one in every 79 extended Swedish families had been impacted by schizophrenia. The proportion of affected families with multiple affected members was 3(.)81%. Recurrence risk estimates for all relative types were strikingly similar to those reported in smaller and older studies. For example, we estimated lambda(sibs) at 8(.)55 [95% confidence interval (CI) 7(.)86-9(.)57] compared with a literature estimate of 8(.)6. Conclusions. In the largest and most comprehensive sample yet studied, we confirm the accepted estimates of recurrence risks for schizophrenia, and provide more accurate estimates of recurrence risks of schizophrenia in relatives, an estimate of the familial impact of schizophrenia, and the multiplex proportion (essential for gauging the generalizability of findings from multiplex pedigrees). These data may be valuable for planning and interpreting genetic studies of schizophrenia.

Subject headings and genre

MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Björk, Camilla (author)
Hultman, Christina M.Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap(Swepub:uu)chrihult (author)
Scolnick, Edward (author)
Sklar, Pamela (author)
Sullivan, Patrick F. (author)
Karolinska InstitutetInstitutionen för neurovetenskap (creator_code:org_t)

Related titles

In:Psychological Medicine36:10, s. 1417-14250033-29171469-8978

Internet link

Find in a library

Psychological Medicine (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Lichtenstein, Pa ...; Björk, Camilla; Hultman, Christi ...; Scolnick, Edward; Sklar, Pamela; Sullivan, Patric ...

Articles in the publication: Psychological Me ...

By the university: Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se