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Concise Review :
Concise Review : Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
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Heslop, James A. (author)
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Hammond, Thomas G. (author)
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Santeramo, Ilaria (author)
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Piella, Agnes Tort (author)
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Hopp, Isabel (author)
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Zhou, Jing (author)
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Baty, Roua (author)
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Graziano, Enrique I. (author)
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Marco, Bernabe Proto (author)
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Caron, Alexis (author)
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- Sköld, Patrik (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Andrews, Peter W. (author)
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Baxter, Melissa A. (author)
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Hay, David C. (author)
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Hamdam, Junnat (author)
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Sharpe, Michaela E. (author)
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Patel, Sara (author)
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Jones, David R. (author)
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Reinhardt, Jens (author)
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Danen, Erik H. J. (author)
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Ben-David, Uri (author)
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Stacey, Glyn (author)
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Bjorquist, Petter (author)
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Piner, Jacqueline (author)
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Mills, John (author)
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Rowe, Cliff (author)
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Pellegrini, Giovanni (author)
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Sethu, Swaminathan (author)
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Antoine, Daniel J. (author)
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Cross, Michael J. (author)
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Murray, Patricia (author)
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Williams, Dominic P. (author)
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Kitteringham, Neil R. (author)
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Goldring, Chris E. P. (author)
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Park, B. Kevin (author)
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(creator_code:org_t)
- 2015-02-26
- 2015
- English.
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In: Stem Cells Translational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 4:4, s. 389-400
- Related links:
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https://stemcellsjou...
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Subject headings
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- The field of stem cell therapeutics is moving ever closer to widespread application in the clinic. However, despite the undoubted potential held by these therapies, the balance between risk and benefit remains difficult to predict. As in any new field, a lack of previous application in man and gaps in the underlying science mean that regulators and investigators continue to look for a balance between minimizing potential risk and ensuring therapies are not needlessly kept from patients. Here, we attempt to identify the important safety issues, assessing the current advances in scientific knowledge and how they may translate to clinical therapeutic strategies in the identification and management of these risks. We also investigate the tools and techniques currently available to researchers during preclinical and clinical development of stem cell products, their utility and limitations, and how these tools may be strategically used in the development of these therapies. We conclude that ensuring safety through cutting-edge science and robust assays, coupled with regular and open discussions between regulators and academic/industrial investigators, is likely to prove the most fruitful route to ensuring the safest possible development of new products.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Adult stem cells
- Autologous stem cell transplantation
- Cellular therapy
- Stem cell expansion
- In vivo tracking
- Pluripotent stem cells
- Stem cell transplantation
- Stem cell
Publication and Content Type
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- By the author/editor
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Heslop, James A.
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Hammond, Thomas ...
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Santeramo, Ilari ...
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Piella, Agnes To ...
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Hopp, Isabel
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Zhou, Jing
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show more...
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Baty, Roua
-
Graziano, Enriqu ...
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Marco, Bernabe P ...
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Caron, Alexis
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Sköld, Patrik
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Andrews, Peter W ...
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Baxter, Melissa ...
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Hay, David C.
-
Hamdam, Junnat
-
Sharpe, Michaela ...
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Patel, Sara
-
Jones, David R.
-
Reinhardt, Jens
-
Danen, Erik H. J ...
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Ben-David, Uri
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Stacey, Glyn
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Bjorquist, Pette ...
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Piner, Jacquelin ...
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Mills, John
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Rowe, Cliff
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Pellegrini, Giov ...
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Sethu, Swaminath ...
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Antoine, Daniel ...
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Cross, Michael J ...
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Murray, Patricia
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Williams, Domini ...
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Kitteringham, Ne ...
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Goldring, Chris ...
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Park, B. Kevin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Medical Biotechn ...
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Stem Cells Trans ...
- By the university
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Uppsala University