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Imaging of Homeosta...
Imaging of Homeostatic, Neoplastic, and Injured Tissues by HA-Based Probes
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Veiseh, Mandana (author)
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Breadner, Daniel (author)
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Ma, Jenny (author)
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Akentieva, Natalia (author)
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Savani, Rashmin C. (author)
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Harrison, Rene (author)
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Mikilus, David (author)
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Collis, Lisa (author)
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- Gustafson, Stefan (author)
- Uppsala universitet,Institutionen för medicinsk och fysiologisk kemi
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Lee, Ting-Yim (author)
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Koropatnick, James (author)
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Luyt, Leonard G. (author)
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Bissell, Mina J. (author)
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Turley, Eva A. (author)
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(creator_code:org_t)
- 2011-12-12
- 2012
- English.
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In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 13:1, s. 12-22
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism, thus providing a flexible imaging strategy for monitoring disease and repair processes. Kinetic analyses confirmed favorable available serum levels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear (technetium-HA, Tc-99m-HA, and iodine-HA, I-125-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (Tc-99m-HA), breast cancer. cells/xenografts (TR-HA, Gd-HA), and vascular injury (I-125-HA, TR-HA). Targeting of HA probes to these sites. appeared to result from selective HA receptor-dependent localization. Our results suggest that HA-based probes, which do not require, polysaccharide backbone modification to achieve favorable half-life and distribution, can detect elevated HA metabolism in homeostatic, injured, and diseased tissues.
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- By the author/editor
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Veiseh, Mandana
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Breadner, Daniel
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Ma, Jenny
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Akentieva, Natal ...
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Savani, Rashmin ...
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Harrison, Rene
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show more...
-
Mikilus, David
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Collis, Lisa
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Gustafson, Stefa ...
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Lee, Ting-Yim
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Koropatnick, Jam ...
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Luyt, Leonard G.
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Bissell, Mina J.
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Turley, Eva A.
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show less...
- Articles in the publication
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Biomacromolecule ...
- By the university
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Uppsala University