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  • Veiseh, Mandana (author)

Imaging of Homeostatic, Neoplastic, and Injured Tissues by HA-Based Probes

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2011-12-12
  • American Chemical Society (ACS),2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-253318
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253318URI
  • https://doi.org/10.1021/bm201143cDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism, thus providing a flexible imaging strategy for monitoring disease and repair processes. Kinetic analyses confirmed favorable available serum levels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear (technetium-HA, Tc-99m-HA, and iodine-HA, I-125-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (Tc-99m-HA), breast cancer. cells/xenografts (TR-HA, Gd-HA), and vascular injury (I-125-HA, TR-HA). Targeting of HA probes to these sites. appeared to result from selective HA receptor-dependent localization. Our results suggest that HA-based probes, which do not require, polysaccharide backbone modification to achieve favorable half-life and distribution, can detect elevated HA metabolism in homeostatic, injured, and diseased tissues.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Breadner, Daniel (author)
  • Ma, Jenny (author)
  • Akentieva, Natalia (author)
  • Savani, Rashmin C. (author)
  • Harrison, Rene (author)
  • Mikilus, David (author)
  • Collis, Lisa (author)
  • Gustafson, StefanUppsala universitet,Institutionen för medicinsk och fysiologisk kemi (author)
  • Lee, Ting-Yim (author)
  • Koropatnick, James (author)
  • Luyt, Leonard G. (author)
  • Bissell, Mina J. (author)
  • Turley, Eva A. (author)
  • Uppsala universitetInstitutionen för medicinsk och fysiologisk kemi (creator_code:org_t)

Related titles

  • In:Biomacromolecules: American Chemical Society (ACS)13:1, s. 12-221525-77971526-4602

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