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Imaging of Homeosta...
Imaging of Homeostatic, Neoplastic, and Injured Tissues by HA-Based Probes
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2011-12-12
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American Chemical Society (ACS),2012
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-253318
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253318URI
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https://doi.org/10.1021/bm201143cDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism, thus providing a flexible imaging strategy for monitoring disease and repair processes. Kinetic analyses confirmed favorable available serum levels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear (technetium-HA, Tc-99m-HA, and iodine-HA, I-125-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (Tc-99m-HA), breast cancer. cells/xenografts (TR-HA, Gd-HA), and vascular injury (I-125-HA, TR-HA). Targeting of HA probes to these sites. appeared to result from selective HA receptor-dependent localization. Our results suggest that HA-based probes, which do not require, polysaccharide backbone modification to achieve favorable half-life and distribution, can detect elevated HA metabolism in homeostatic, injured, and diseased tissues.
Added entries (persons, corporate bodies, meetings, titles ...)
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Breadner, Daniel
(author)
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Ma, Jenny
(author)
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Akentieva, Natalia
(author)
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Savani, Rashmin C.
(author)
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Harrison, Rene
(author)
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Mikilus, David
(author)
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Collis, Lisa
(author)
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Gustafson, StefanUppsala universitet,Institutionen för medicinsk och fysiologisk kemi
(author)
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Lee, Ting-Yim
(author)
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Koropatnick, James
(author)
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Luyt, Leonard G.
(author)
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Bissell, Mina J.
(author)
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Turley, Eva A.
(author)
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Uppsala universitetInstitutionen för medicinsk och fysiologisk kemi
(creator_code:org_t)
Related titles
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In:Biomacromolecules: American Chemical Society (ACS)13:1, s. 12-221525-77971526-4602
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Veiseh, Mandana
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Breadner, Daniel
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Ma, Jenny
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Akentieva, Natal ...
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Harrison, Rene
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Mikilus, David
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Collis, Lisa
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Gustafson, Stefa ...
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Lee, Ting-Yim
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Koropatnick, Jam ...
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Luyt, Leonard G.
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Bissell, Mina J.
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Turley, Eva A.
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Uppsala University