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Regulatory mutation...
Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation underlying Dun camouflage colour in horses
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- Imsland, Freyja (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- McGowan, Kelly (author)
- HudsonAlpha Institute for Biotechnology / Department of Genetics, Stanford University School of Medicine
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- Rubin, Carl-Johan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Henegar, Corneliu (author)
- Department of Genetics, Stanford University School of Medicine
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- Sundström, Elisabeth (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Berglund, Jonas (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Schwochow, Doreen (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,National Institute of Agricultural Research (INRA),Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences / INRA - AgroParisTech
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- Gustafson, Ulla (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
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- Imsland, Páll (author)
- Menntaskólinn við Hamrahlíð
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- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Institute of Harvard and MIT
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- Lindgren, Gabriella (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
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- Mikko, Sofia (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
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- Millon, Lee (author)
- Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis
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- Wade, Claire (author)
- Broad Institute of Harvard and MIT
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- Schubert, Mikkel (author)
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen
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- Orlando, Ludovic (author)
- Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen
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- Penedo, Maria Cecilia T. (author)
- Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis
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- Barsh, Gregory S. (author)
- HudsonAlpha Institute for Biotechnology / Department of Genetics, Stanford University School of Medicine
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Texas A&M University,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University
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(creator_code:org_t)
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- 2015-12-21
- 2016
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:2, s. 152-158
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- Dun is a wild-type coat color in horses characterized by pigment dilution with a striking pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle melanocytes. Most domestic horses are non-dun, a more intensely pigmented phenotype caused by regulatory mutations impairing TBX3 expression in the hair follicle, resulting in a more circumferential distribution of melanocytes and pigment granules in individual hairs. We identified two different alleles (non-dun1 and non-dun2) causing non-dun color. non-dun2 is a recently derived allele, whereas the Dun and non-dun1 alleles are found in ancient horse DNA, demonstrating that this polymorphism predates horse domestication. These findings uncover a new developmental role for T-box genes and new aspects of hair follicle biology and pigmentation.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Imsland, Freyja
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McGowan, Kelly
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Rubin, Carl-Joha ...
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Henegar, Corneli ...
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Sundström, Elisa ...
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Berglund, Jonas
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show more...
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Schwochow, Doree ...
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Gustafson, Ulla
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Imsland, Páll
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Lindblad-Toh, Ke ...
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Lindgren, Gabrie ...
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Mikko, Sofia
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Millon, Lee
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Wade, Claire
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Schubert, Mikkel
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Orlando, Ludovic
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Penedo, Maria Ce ...
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Barsh, Gregory S ...
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Andersson, Leif
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences