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3-Substituted pyraz...
3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1
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- Pelcman, Benjamin (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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Sanin, Andrei (author)
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- Nilsson, Peter (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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No, Kiyo (author)
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- Schaal, Wesley (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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Öhrman, Sara (author)
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Krog-Jensen, Christian (author)
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- Forsell, Pontus (author)
- Karolinska Institutet
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- Hallberg, Anders (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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- Larhed, Mats (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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Boesen, Thomas (author)
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Kromann, Hasse (author)
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Vogensen, Stine Byskov (author)
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Groth, Thomas (author)
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- Claesson, Hans-Erik (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 25:15, s. 3024-3029
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pelcman, Benjami ...
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Sanin, Andrei
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Nilsson, Peter
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No, Kiyo
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Schaal, Wesley
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Öhrman, Sara
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show more...
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Krog-Jensen, Chr ...
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Forsell, Pontus
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Hallberg, Anders
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Larhed, Mats
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Boesen, Thomas
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Kromann, Hasse
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Vogensen, Stine ...
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Groth, Thomas
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Claesson, Hans-E ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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Bioorganic & Med ...
- By the university
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Uppsala University
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Karolinska Institutet