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Treatment of venous...
Treatment of venous thromboembolism in cancer patients with dalteparin for up to 12months : the DALTECAN Study
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Francis, C. W. (author)
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Kessler, C. M. (author)
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Goldhaber, S. Z. (author)
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Kovacs, M. J. (author)
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Monreal, M. (author)
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Huisman, M. V. (author)
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- Bergqvist, David (author)
- Uppsala universitet,Kärlkirurgi
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Turpie, A. G. (author)
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Ortel, T. L. (author)
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Spyropoulos, A. C. (author)
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Pabinger, I. (author)
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Kakkar, A. K. (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 13:6, s. 1028-1035
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BackgroundTreatment of venous thromboembolism (VTE) in patients with cancer has a high rate of recurrence and bleeding complications. Guidelines recommend low-molecular-weight heparin (LMWH) for at least 3-6months and possibly indefinitely for patients with active malignancy. There are, however, few data supporting treatment with LMWH beyond 6months. The primary aim of the DALTECAN study (NCT00942968) was to determine the safety of dalteparin between 6 and 12months in cancer-associated VTE. MethodsPatients with active cancer and newly diagnosed VTE were enrolled in a prospective, multicenter study and received subcutaneous dalteparin for 12months. The rates of bleeding and recurrent VTE were evaluated at months 1, 2-6 and 7-12. FindingsOf 334 patients enrolled, 185 and 109 completed 6 and 12months of therapy; 49.1% had deep vein thrombosis (DVT); 38.9% had pulmonary embolism (PE); and 12.0% had both on presentation. The overall frequency of major bleeding was 10.2% (34/334). Major bleeding occurred in 3.6% (12/334) in the first month, and 1.1% (14/1237) and 0.7% (8/1086) per patient-month during months 2-6 and 7-12, respectively. Recurrent VTE occurred in 11.1% (37/334); the incidence rate was 5.7% (19/334) for month 1, 3.4% (10/296) during months 2-6, and 4.1% (8/194) during months 7-12. One hundred and sixteen patients died, four due to recurrent VTE and two due to bleeding. ConclusionMajor bleeding was less frequent during dalteparin therapy beyond 6months. The risk of developing major bleeding complications or VTE recurrence was greatest in the first month of therapy and lower over the subsequent 11 months.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cancer
- dalteparin
- deep vein thrombosis
- low-molecular-weight heparin
- pulmonary embolism
- venous thromboembolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Francis, C. W.
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Kessler, C. M.
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Goldhaber, S. Z.
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Kovacs, M. J.
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Monreal, M.
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Huisman, M. V.
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show more...
-
Bergqvist, David
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Turpie, A. G.
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Ortel, T. L.
-
Spyropoulos, A. ...
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Pabinger, I.
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Kakkar, A. K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Throm ...
- By the university
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Uppsala University