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Human Adaptation to...
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Schlebusch, Carina M.Uppsala universitet,Evolutionsbiologi,Uppsala University
(author)
Human Adaptation to Arsenic-Rich Environments
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-03-03
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Oxford University Press (OUP),2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-258034
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258034URI
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https://doi.org/10.1093/molbev/msv046DOI
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https://lup.lub.lu.se/record/5265296URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131451443URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Adaptation drives genomic changes; however, evidence of specific adaptations in humans remains limited. We found that inhabitants of the northern Argentinean Andes, an arid region where elevated arsenic concentrations in available drinking water is common, have unique arsenic metabolism, with efficient methylation and excretion of the major metabolite dimethylated arsenic and a less excretion of the highly toxic monomethylated metabolite. We genotyped women from this population for 4,301,332 single nucleotide polymorphisms (SNPs) and found a strong association between the AS3MT (arsenic [+3 oxidation state] methyltransferase) gene and mono- and dimethylated arsenic in urine, suggesting that AS3MT functions as the major gene for arsenic metabolism in humans. We found strong genetic differentiation around AS3MT in the Argentinean Andes population, compared with a highly related Peruvian population (F-ST = 0.014) from a region with much less environmental arsenic. Also, 13 of the 100 SNPs with the highest genome-wide Locus-Specific Branch Length occurred near AS3MT. In addition, our examination of extended haplotype homozygosity indicated a selective sweep of the Argentinean Andes population, in contrast to Peruvian and Colombian populations. Our data show that adaptation to tolerate the environmental stressor arsenic has likely driven an increase in the frequencies of protective variants of AS3MT, providing the first evidence of human adaptation to a toxic chemical.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Gattepaille, Lucie M.Uppsala University,Uppsala universitet,Evolutionsbiologi(Swepub:uu)lucga982
(author)
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Engström, KarinLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-ksk
(author)
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Vahter, MarieKarolinska Institutet
(author)
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Jakobsson, MattiasUppsala University,Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)matja323
(author)
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Broberg Palmgren, KarinLund University(Swepub:lu)kgen-kbr
(author)
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Uppsala universitetEvolutionsbiologi
(creator_code:org_t)
Related titles
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In:Molecular biology and evolution: Oxford University Press (OUP)32:6, s. 1544-15550737-40381537-1719
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