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Duffy antigen recep...
Duffy antigen receptor genetic variant and the association with Interleukin 8 levels
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Velasquez, Ilais Moreno (author)
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- Kumar, Jitender (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Silveira, Angela (author)
- Karolinska Institutet
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- Leander, Karin (author)
- Karolinska Institutet
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- Berglund, Anita (author)
- Karolinska Institutet
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Kardiovaskulär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Hamsten, Anders (author)
- Karolinska Institutet
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- de Faire, Ulf (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Cytokine. - : Elsevier BV. - 1043-4666 .- 1096-0023. ; 72:2, s. 178-184
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
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- The aim of this study is to identify loci associated with circulating levels of Interleukin 8 (IL8). We investigated the associations of 121,445 single nucleotide polymorphisms (SNPs) from the Illumina 200K CardioMetabochip with IL8 levels in 1077 controls from the Stockholm Heart Epidemiology Program (SHEEP) study, using linear regression under an additive model of inheritance. Five SNPs (rs12075A/G, rs13179413C/T, rs6907989T/A, rs9352745A/C, rs1779553T/C) reached the predefined threshold of genome-wide significance (p < 1.0 x 10(-5)) and were tested for in silico replication in three independent populations, derived from the PIVUS, MDC-CC and SCARF studies. IL8 was measured in serum (SHEEP, PIVUS) and plasma (MDC-CC, SCARF). The strongest association was found with the SNP rs12075 A/G, Asp42Gly (p = 1.6 x 10(-6)), mapping to the Duffy antigen receptor for chemokines (DARC) gene on chromosome 1. The minor allele G was associated with 15.6% and 10.4% reduction in serum IL8 per copy of the allele in SHEEP and PIVUS studies respectively. No association was observed between rs12075 and plasma IL8. Conclusion: rs12075 was associated with serum levels but not with plasma levels of IL8. It is likely that serum IL8 represents the combination of levels of circulating plasma IL8 and additional chemokine liberated from the erythrocyte DARC reservoir due to clotting. These findings highlight the importance of understanding ILS as a biomarker in cardiometabolic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Interleukin 8
- Duffy antigen receptor for chemokine
- Genetic variants
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cytokine
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- By the author/editor
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Velasquez, Ilais ...
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Kumar, Jitender
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Björkbacka, Harr ...
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Nilsson, Jan
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Silveira, Angela
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Leander, Karin
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show more...
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Berglund, Anita
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Strawbridge, Ron ...
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Ärnlöv, Johan
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Melander, Olle
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Almgren, Peter
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Lind, Lars
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Hamsten, Anders
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de Faire, Ulf
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Gigante, Bruna
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Cytokine
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Högskolan Dalarna