Association of Cardiometabolic Multimorbidity With Mortality: The Emerging Risk Factors Collaboration

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Fältnamn	Indikatorer	Metadata
000		07763naa a2201333 4500
001		oai:DiVA.org:uu-259089
003		SwePub
008		150727s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2590892 URI
024	7	a https://doi.org/10.1001/jama.2015.70082 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Di Angelantonio, Emanuele4 aut
245	1 0	a Association of Cardiometabolic Multimorbidity With Mortality :b The Emerging Risk Factors Collaboration
264	1	b American Medical Association (AMA),c 2015
338		a print2 rdacarrier
520		a IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing.OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128 843 deaths). The HRs from the Emerging Risk Factors Collaboration were compared with those from the UK Biobank (499 808 participants; years of baseline surveys: 2006-2010; latest mortality follow-up: November 2013; 7995 deaths). Cumulative survival was estimated by applying calculated age-specific HRs for mortality to contemporary US age-specific death rates. EXPOSURES A history of 2 or more of the following: diabetes mellitus, stroke, myocardial infarction (MI).MAIN OUTCOMES AND MEASURES All-cause mortality and estimated reductions in life expectancy.RESULTS In participants in the Emerging Risk Factors Collaboration without a history of diabetes, stroke, or MI at baseline (reference group), the all-cause mortality rate adjusted to the age of 60 years was 6.8 per 1000 person-years. Mortality rates per 1000 person-years were 15.6 in participants with a history of diabetes, 16.1 in those with stroke, 16.8 in those with MI, 32.0 in those with both diabetes and MI, 32.5 in those with both diabetes and stroke, 32.8 in those with both stroke and MI, and 59.5 in those with diabetes, stroke, and MI. Compared with the reference group, the HRs for all-cause mortality were 1.9 (95% CI, 1.8-2.0) in participants with a history of diabetes, 2.1 (95% CI, 2.0-2.2) in those with stroke, 2.0 (95% CI, 1.9-2.2) in those with MI, 3.7 (95% CI, 3.3-4.1) in those with both diabetes and MI, 3.8 (95% CI, 3.5-4.2) in those with both diabetes and stroke, 3.5 (95% CI, 3.1-4.0) in those with both stroke and MI, and 6.9 (95% CI, 5.7-8.3) in those with diabetes, stroke, and MI. The HRs from the Emerging Risk Factors Collaboration were similar to those from the more recently recruited UK Biobank. The HRs were little changed after further adjustment for markers of established intermediate pathways (eg, levels of lipids and blood pressure) and lifestyle factors (eg, smoking, diet). At the age of 60 years, a history of any 2 of these conditions was associated with 12 years of reduced life expectancy and a history of all 3 of these conditions was associated with 15 years of reduced life expectancy.CONCLUSIONS AND RELEVANCE Mortality associated with a history of diabetes, stroke, or MI was similar for each condition. Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Kaptoge, Stephen4 aut
700	1	a Wormser, David4 aut
700	1	a Willeit, Peter4 aut
700	1	a Butterworth, Adam S.4 aut
700	1	a Bansal, Narinder4 aut
700	1	a O'Keeffe, Linda M.4 aut
700	1	a Gao, Pei4 aut
700	1	a Wood, Angela M.4 aut
700	1	a Burgess, Stephen4 aut
700	1	a Freitag, Daniel F.4 aut
700	1	a Pennells, Lisa4 aut
700	1	a Peters, Sanne A.4 aut
700	1	a Hart, Carole L.4 aut
700	1	a Haheim, Lise Lund4 aut
700	1	a Gillum, Richard F.4 aut
700	1	a Nordestgaard, Borge G.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Yeap, Bu B.4 aut
700	1	a Knuiman, Matthew W.4 aut
700	1	a Nietert, Paul J.4 aut
700	1	a Kauhanen, Jussi4 aut
700	1	a Salonen, Jukka T.4 aut
700	1	a Kuller, Lewis H.4 aut
700	1	a Simons, Leon A.4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Barrett-Connor, Elizabeth4 aut
700	1	a Selmer, Randi4 aut
700	1	a Crespo, Carlos J.4 aut
700	1	a Rodriguez, Beatriz4 aut
700	1	a Verschuren, W. M. Monique4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Svärdsudd, Kurt,d 1942-u Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)kurtsvar
700	1	a van der Harst, Pim4 aut
700	1	a Bjorkelund, Cecilia4 aut
700	1	a Wilhelmsen, Lars4 aut
700	1	a Wallace, Robert B.4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Amouyel, Philippe4 aut
700	1	a Barr, Elizabeth L. M.4 aut
700	1	a Iso, Hiroyasu4 aut
700	1	a Onat, Altan4 aut
700	1	a Trevisan, Maurizio4 aut
700	1	a D'Agostino, Ralph B., Sr.4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Kavousi, Maryam4 aut
700	1	a Welin, Lennart4 aut
700	1	a Roussel, Ronan4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Sato, Shinichi4 aut
700	1	a Davidson, Karina W.4 aut
700	1	a Howard, Barbara V.4 aut
700	1	a Leening, Maarten4 aut
700	1	a Rosengren, Annika4 aut
700	1	a Dorr, Marcus4 aut
700	1	a Deeg, Dorly J. H.4 aut
700	1	a Kiechl, Stefan4 aut
700	1	a Stehouwer, Coen D. A.4 aut
700	1	a Nissinen, Aulikki4 aut
700	1	a Giampaoli, Simona4 aut
700	1	a Donfrancesco, Chiara4 aut
700	1	a Kromhout, Daan4 aut
700	1	a Price, Jackie F.4 aut
700	1	a Peters, Annette4 aut
700	1	a Meade, Tom W.4 aut
700	1	a Casiglia, Edoardo4 aut
700	1	a Lawlor, Debbie A.4 aut
700	1	a Gallacher, John4 aut
700	1	a Nagel, Dorothea4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Assmann, Gerd4 aut
700	1	a Dagenais, Gilles R.4 aut
700	1	a Jukema, J. Wouter4 aut
700	1	a Sundström, Johanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)johasund
700	1	a Woodward, Mark4 aut
700	1	a Brunner, Eric J.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Whitsel, Eric A.4 aut
700	1	a Njolstad, Inger4 aut
700	1	a Hedblad, Bo4 aut
700	1	a Wassertheil-Smoller, Sylvia4 aut
700	1	a Engstrom, Gunnar4 aut
700	1	a Rosamond, Wayne D.4 aut
700	1	a Selvin, Elizabeth4 aut
700	1	a Sattar, Naveed4 aut
700	1	a Thompson, Simon G.4 aut
700	1	a Danesh, John4 aut
710	2	a Uppsala universitetb Allmänmedicin och preventivmedicin4 org
773	0	t Journal of the American Medical Association (JAMA)d : American Medical Association (AMA)g 314:1, s. 52-60q 314:1<52-60x 0098-7484x 1538-3598
856	4	u https://jamanetwork.com/journals/jama/articlepdf/2382980/joi150068.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259089
856	4 8	u https://doi.org/10.1001/jama.2015.7008

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By the author/editor: Di Angelantonio, ...; Kaptoge, Stephen; Wormser, David; Willeit, Peter; Butterworth, Ada ...; Bansal, Narinder; show more...; O'Keeffe, Linda ...; Gao, Pei; Wood, Angela M.; Burgess, Stephen; Freitag, Daniel ...; Pennells, Lisa; Peters, Sanne A.; Hart, Carole L.; Haheim, Lise Lun ...; Gillum, Richard ...; Nordestgaard, Bo ...; Psaty, Bruce M.; Yeap, Bu B.; Knuiman, Matthew ...; Nietert, Paul J.; Kauhanen, Jussi; Salonen, Jukka T ...; Kuller, Lewis H.; Simons, Leon A.; van der Schouw, ...; Barrett-Connor, ...; Selmer, Randi; Crespo, Carlos J ...; Rodriguez, Beatr ...; Verschuren, W. M ...; Salomaa, Veikko; Svärdsudd, Kurt, ...; van der Harst, P ...; Bjorkelund, Ceci ...; Wilhelmsen, Lars; Wallace, Robert ...; Brenner, Hermann; Amouyel, Philipp ...; Barr, Elizabeth ...; Iso, Hiroyasu; Onat, Altan; Trevisan, Mauriz ...; D'Agostino, Ralp ...; Cooper, Cyrus; Kavousi, Maryam; Welin, Lennart; Roussel, Ronan; Hu, Frank B.; Sato, Shinichi; Davidson, Karina ...; Howard, Barbara ...; Leening, Maarten; Rosengren, Annik ...; Dorr, Marcus; Deeg, Dorly J. H ...; Kiechl, Stefan; Stehouwer, Coen ...; Nissinen, Aulikk ...; Giampaoli, Simon ...; Donfrancesco, Ch ...; Kromhout, Daan; Price, Jackie F.; Peters, Annette; Meade, Tom W.; Casiglia, Edoard ...; Lawlor, Debbie A ...; Gallacher, John; Nagel, Dorothea; Franco, Oscar H.; Assmann, Gerd; Dagenais, Gilles ...; Jukema, J. Woute ...; Sundström, Johan; Woodward, Mark; Brunner, Eric J.; Khaw, Kay-Tee; Wareham, Nichola ...; Whitsel, Eric A.; Njolstad, Inger; Hedblad, Bo; Wassertheil-Smol ...; Engstrom, Gunnar; Rosamond, Wayne ...; Selvin, Elizabet ...; Sattar, Naveed; Thompson, Simon ...; Danesh, John; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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