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Disruption of Memor...
Disruption of Memory Reconsolidation Erases a Fear Memory Trace in the Human Amygdala : An 18-Month Follow-Up.
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- Björkstrand, Johannes (author)
- Uppsala universitet,Institutionen för psykologi
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- Ågren, Thomas (author)
- Uppsala universitet,Institutionen för psykologi
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- Frick, Andreas (author)
- Uppsala universitet,Institutionen för psykologi
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- Engman, Jonas (author)
- Uppsala universitet,Institutionen för psykologi
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- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi
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- Fredrikson, Mats (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi
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(creator_code:org_t)
- 2015-07-01
- 2015
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:7, s. e0129393-
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Abstract
Subject headings
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- Fear memories can be attenuated by reactivation followed by disrupted reconsolidation. Using functional magnetic resonance imaging we recently showed that reactivation and reconsolidation of a conditioned fear memory trace in the basolateral amygdala predicts subsequent fear expression over two days, while reactivation followed by disrupted reconsolidation abolishes the memory trace and suppresses fear. In this follow-up study we demonstrate that the behavioral effect persists over 18 months reflected in superior reacquisition after undisrupted, as compared to disrupted reconsolidation, and that neural activity in the basolateral amygdala representing the initial fear memory predicts return of fear. We conclude that disrupting reconsolidation have long lasting behavioral effects and may permanently erase the fear component of an amygdala-dependent memory.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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