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Disruption of Memor...
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Björkstrand, JohannesUppsala universitet,Institutionen för psykologi
(author)
Disruption of Memory Reconsolidation Erases a Fear Memory Trace in the Human Amygdala : An 18-Month Follow-Up.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-07-01
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Public Library of Science (PLoS),2015
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-259785
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259785URI
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https://doi.org/10.1371/journal.pone.0129393DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131672493URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Boethius stiftelse PSYK2010/143, Swedish Council for Working Life and Social Research, Heumanska stiftelsen
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Fear memories can be attenuated by reactivation followed by disrupted reconsolidation. Using functional magnetic resonance imaging we recently showed that reactivation and reconsolidation of a conditioned fear memory trace in the basolateral amygdala predicts subsequent fear expression over two days, while reactivation followed by disrupted reconsolidation abolishes the memory trace and suppresses fear. In this follow-up study we demonstrate that the behavioral effect persists over 18 months reflected in superior reacquisition after undisrupted, as compared to disrupted reconsolidation, and that neural activity in the basolateral amygdala representing the initial fear memory predicts return of fear. We conclude that disrupting reconsolidation have long lasting behavioral effects and may permanently erase the fear component of an amygdala-dependent memory.
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Ågren, ThomasUppsala universitet,Institutionen för psykologi(Swepub:uu)thoag299
(author)
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Frick, AndreasUppsala universitet,Institutionen för psykologi(Swepub:uu)andfr548
(author)
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Engman, JonasUppsala universitet,Institutionen för psykologi(Swepub:uu)jonen754
(author)
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Larsson, Elna-MarieUppsala universitet,Radiologi(Swepub:uu)elnla305
(author)
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Furmark, TomasUppsala universitet,Institutionen för psykologi(Swepub:uu)tomafurm
(author)
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Fredrikson, MatsKarolinska Institutet,Uppsala universitet,Institutionen för psykologi(Swepub:uu)matsfred
(author)
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Uppsala universitetInstitutionen för psykologi
(creator_code:org_t)
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In:PLOS ONE: Public Library of Science (PLoS)10:7, s. e0129393-1932-6203
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