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History of Maternal...
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Karalexi, M ADepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
(author)
History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring : Differentials by Miscarriage or Stillbirth History and Disease Subtype.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-07-14
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Wiley,2015
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LIBRIS-ID:oai:DiVA.org:uu-260940
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-260940URI
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https://doi.org/10.1111/ppe.12207DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: Despite the putative intrauterine origins of childhood (0-14 years) leukaemia, it is complex to assess the impact of perinatal factors on disease onset. Results on the association of maternal history of fetal loss (miscarriage/stillbirth) with specific disease subtypes in the subsequent offspring are in conflict. We sought to investigate whether miscarriage and stillbirth may have different impacts on the risk of acute lymphoblastic leukaemia (ALL) and of its main immunophenotypes (B-cell and T-cell ALL), as contrasted to acute myeloid leukaemia (AML).METHODS: One thousand ninety-nine ALL incidents (957 B-ALL) and 131 AML cases along with 1:1 age and gender-matched controls derived from the Nationwide Registry for Childhood Hematological Malignancies and Brain Tumors (1996-2013) were studied. Multivariable regression models were used to assess the roles of previous miscarriage(s) and stillbirth(s) on ALL (overall, B-, T-ALL) and AML, controlling for potential confounders.RESULTS: Statistically significant exposure and disease subtype-specific associations of previous miscarriage(s) exclusively with AML [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.00, 2.81] and stillbirth(s) with ALL [OR 4.82, 95% CI 1.63, 14.24] and B-ALL particularly, emerged.CONCLUSION: Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history confined to ALL (specifically B-ALL). If confirmed and further supported by studies revealing underlying mechanisms, these results may shed light on the divergent leukemogenesis processes.
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Skalkidou, Alkistis,1977-Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa(Swepub:uu)alksk607
(author)
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Thomopoulos, T PDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Belechri, MDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Biniaris-Georgallis, S-IDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Bouka, EDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Baka, MDepartment of Pediatric Hematology-Oncology, 'Pan. & Agl. Kyriakou' Children's Hospital, Athens, Greece
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Hatzipantelis, E2nd Department of Pediatrics, Aristotelion University of Thessaloniki, AHEPA General Hospital, Greece
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Kourti, MDepartment of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece
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Polychronopoulou, SDepartment of Pediatric Haematology-Oncology, 'Aghia Sophia' Children's Hospital, Athens, Greece
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Sidi, VDepartment of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece
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Stiakaki, EDepartment of Pediatric Hematology-Oncology, University Hospital of Heraklion, Greece
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Moschovi, MHaematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, 'Aghia Sophia' Children's Hospital, Greece
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Dessypris, NDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Petridou, E ThDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, Greece
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Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, GreeceObstetrik & gynekologi
(creator_code:org_t)
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In:Paediatric and Perinatal Epidemiology: Wiley29:5, s. 453-610269-50221365-3016
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Karalexi, M A
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Skalkidou, Alkis ...
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Thomopoulos, T P
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Belechri, M
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Biniaris-Georgal ...
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Bouka, E
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Baka, M
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Hatzipantelis, E
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Kourti, M
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Polychronopoulou ...
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Sidi, V
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Stiakaki, E
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Moschovi, M
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Dessypris, N
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Petridou, E Th
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