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- Zang, GuangxiangUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Activated pancreatic stellate cells can impair pancreatic islet function in mice
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-04-08
- Uppsala Medical Society,2015
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-261989
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261989URI
- https://doi.org/10.3109/03009734.2015.1032453DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Background. Pancreatic or islet fibrosis is often associated with activated pancreatic stellate cells (PSCs). PSCs are considered not only to promote fibrosis, but also to be associated with glucose intolerance in some diseases. We therefore evaluated morphological and functional relationships between islets and PSCs in the normal mouse pancreas and transplanted islets. Methods. Immunohistochemistry was used to map the presence of PSCs in the normal mouse pancreas and islets implanted under the renal capsule. We isolated and cultured mouse PSCs and characterized them morphologically by immunofluorescence staining. Furthermore, we measured their cytokine production and determined their effects on insulin release from simultaneously cultured islets. Results. PSCs were scattered throughout the pancreas, with occasional cells within the islets, particularly in the islet capsule. In islet transplants they were found mainly in the graft periphery. Cultured PSCs became functionally activated and produced several cytokines. Throughout the culture period they linearly increased their production of interleukin-6 and mammalian keratinocyte-derived chemokine. PSC cytokine production was not affected by acute hyperglycemia. Syngeneic islets cocultured with PSCs for 24-48 h increased their insulin release and lowered their insulin content. However, short-term insulin release in batch-type incubations was unaffected after 48 h of co-culture. Increased islet cell caspase-3 activation and a decreased islet cell replication were consistently observed after co-culture for 2 or 7 days. Conclusion. Activated PSCs may contribute to impaired islet endocrine function seen in exocrine pancreatitis and in islet fibrosis associated with some cases of type 2 diabetes.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Beta-cell replication
- insulin release
- pancreatic islets
- stellate cells
Added entries (persons, corporate bodies, meetings, titles ...)
- Sandberg, MonicaUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)mosan330 (author)
- Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi,Transplantation och regenerativ medicin(Swepub:uu)perocarl (author)
- Welsh, NilsUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)nilswels (author)
- Jansson, LeifUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)leifjans (author)
- Barbu, AndreeaUppsala universitet,Institutionen för medicinsk cellbiologi,Klinisk immunologi(Swepub:uu)andrbarb (author)
- Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)
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- In:Upsala Journal of Medical Sciences: Uppsala Medical Society120:3, s. 169-1800300-97342000-1967
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