Search: onr:"swepub:oai:DiVA.org:uu-264207" >
Bronchoconstriction...
Bronchoconstriction induced by inhaled methacholine delays desflurane uptake and elimination in a piglet model
-
- Kretzschmar, Moritz (author)
- Uppsala universitet,Hedenstiernalaboratoriet,Klinisk fysiologi
-
- Kozian, Alf (author)
- Uppsala universitet,Klinisk fysiologi
-
Baumgardner, James E (author)
-
show more...
-
Schreiber, Jens (author)
-
- Hedenstierna, Göran (author)
- Uppsala universitet,Klinisk fysiologi
-
- Larsson, Anders (author)
- Uppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet
-
Hachenberg, Thomas (author)
-
- Schilling, Thomas (author)
- Uppsala universitet,Klinisk fysiologi
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
-
In: Respiratory Physiology & Neurobiology. - : Elsevier BV. - 1569-9048 .- 1878-1519. ; 220, s. 88-94
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Bronchoconstriction is a hallmark of asthma and impairs gas exchange. We hypothesized that pharmacokinetics of volatile anesthetics would be affected by bronchoconstriction. Ventilation/perfusion (V̇A/Q̇) ratios and pharmacokinetics of desflurane in both healthy state and during inhalational administration of methacholine (MCh) to double peak airway pressure were studied in a piglet model. In piglets, MCh administration by inhalation (100μg/ml, n=6) increased respiratory resistance, impaired V̇A/Q̇ distribution, increased shunt, and decreased paO2 in all animals. The uptake and elimination of desflurane in arterial blood was delayed by nebulization of MCh, as determined by Micropore Membrane Inlet Mass Spectrometry (wash-in time to P50, healthy vs. inhalation: 0.5min vs. 1.1min, to P90: 4.0min vs. 14.8min). Volatile elimination was accordingly delayed. Inhaled methacholine induced severe bronchoconstriction and marked inhomogeneous V̇A/Q̇ distribution in pigs, which is similar to findings in human asthma exacerbation. Furthermore, MCh-induced bronchoconstriction delayed both uptake and elimination of desflurane. These findings might be considered when administering inhalational anesthesia to asthmatic patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Physiology
- Fysiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database