onr:"swepub:oai:DiVA.org:uu-264215"
Search: onr:"swepub:oai:DiVA.org:uu-264215" > Protective versus C...
- 1 of 1
- Previous record
- Next record
- To hitlist
Protective versus Conventional Ventilation for Surgery : A Systematic Review and Individual Patient Data Meta-analysis
- Serpa Neto, Ary (author)
- Hemmes, Sabrine N T (author)
- Barbas, Carmen S V (author)
- show more...
- Beiderlinden, Martin (author)
- Biehl, Michelle (author)
- Binnekade, Jan M (author)
- Canet, Jaume (author)
- Fernandez-Bustamante, Ana (author)
- Futier, Emmanuel (author)
- Gajic, Ognjen (author)
- Jaber, Samir (author)
- Kozian, Alf (author)
- Licker, Marc (author)
- Lin, Wen-Qian (author)
- Maslow, Andrew D (author)
- Memtsoudis, Stavros G (author)
- Reis Miranda, Dinis (author)
- Moine, Pierre (author)
- Ng, Thomas (author)
- Paparella, Domenico (author)
- Putensen, Christian (author)
- Ranieri, Marco (author)
- Scavonetto, Federica (author)
- Schilling, Thomas (author)
- Schmid, Werner (author)
- Selmo, Gabriele (author)
- Severgnini, Paolo (author)
- Sprung, Juraj (author)
- Sundar, Sugantha (author)
- Talmor, Daniel (author)
- Treschan, Tanja (author)
- Unzueta, Carmen (author)
- Weingarten, Toby N (author)
- Wolthuis, Esther K (author)
- Wrigge, Hermann (author)
- Gama de Abreu, Marcelo (author)
- Pelosi, Paolo (author)
- Schultz, Marcus J (author)
- show less...
- (creator_code:org_t)
- 2015
- 2015
- English.
- In: Anesthesiology. - 0003-3022 .- 1528-1175. ; 123:1, s. 66-78
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND: Recent studies show that intraoperative mechanical ventilation using low tidal volumes (VT) can prevent postoperative pulmonary complications (PPCs). The aim of this individual patient data meta-analysis is to evaluate the individual associations between VT size and positive end-expiratory pressure (PEEP) level and occurrence of PPC.METHODS: Randomized controlled trials comparing protective ventilation (low VT with or without high levels of PEEP) and conventional ventilation (high VT with low PEEP) in patients undergoing general surgery. The primary outcome was development of PPC. Predefined prognostic factors were tested using multivariate logistic regression.RESULTS: Fifteen randomized controlled trials were included (2,127 patients). There were 97 cases of PPC in 1,118 patients (8.7%) assigned to protective ventilation and 148 cases in 1,009 patients (14.7%) assigned to conventional ventilation (adjusted relative risk, 0.64; 95% CI, 0.46 to 0.88; P < 0.01). There were 85 cases of PPC in 957 patients (8.9%) assigned to ventilation with low VT and high PEEP levels and 63 cases in 525 patients (12%) assigned to ventilation with low VT and low PEEP levels (adjusted relative risk, 0.93; 95% CI, 0.64 to 1.37; P = 0.72). A dose-response relationship was found between the appearance of PPC and VT size (R = 0.39) but not between the appearance of PPC and PEEP level (R = 0.08).CONCLUSIONS: These data support the beneficial effects of ventilation with use of low VT in patients undergoing surgery. Further trials are necessary to define the role of intraoperative higher PEEP to prevent PPC during nonopen abdominal surgery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Physiology
- Fysiologi
- Anaesthesiology and Intensive Care
- Anestesiologi och intensivvård
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Anesthesiology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Serpa Neto, Ary
- Hemmes, Sabrine ...
- Barbas, Carmen S ...
- Beiderlinden, Ma ...
- Biehl, Michelle
- Binnekade, Jan M
- show more...
- Canet, Jaume
- Fernandez-Bustam ...
- Futier, Emmanuel
- Gajic, Ognjen
- Hedenstierna, Gö ...
- Hollmann, Markus ...
- Jaber, Samir
- Kozian, Alf
- Licker, Marc
- Lin, Wen-Qian
- Maslow, Andrew D
- Memtsoudis, Stav ...
- Reis Miranda, Di ...
- Moine, Pierre
- Ng, Thomas
- Paparella, Domen ...
- Putensen, Christ ...
- Ranieri, Marco
- Scavonetto, Fede ...
- Schilling, Thoma ...
- Schmid, Werner
- Selmo, Gabriele
- Severgnini, Paol ...
- Sprung, Juraj
- Sundar, Sugantha
- Talmor, Daniel
- Treschan, Tanja
- Unzueta, Carmen
- Weingarten, Toby ...
- Wolthuis, Esther ...
- Wrigge, Hermann
- Gama de Abreu, M ...
- Pelosi, Paolo
- Schultz, Marcus ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Anesthesiology a ...
- Articles in the publication
- Anesthesiology
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
