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Genome-wide associa...
Genome-wide association study of warfarin maintenance dose in a Brazilian sample
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- Parra, Esteban J. (author)
- Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada.
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- Botton, Mariana R. (author)
- Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil.
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- Perini, Jamila A. (author)
- Inst Nacl Canc, Div Pharmacol, Rio De Janeiro, Brazil.
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- Krithika, S. (author)
- Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada.
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- Bourgeois, Stephane (author)
- Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
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- Johnson, Todd A. (author)
- RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Tokyo, Japan.
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- Tsunoda, Tatsuhiko (author)
- RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Tokyo, Japan.
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- Pirmohamed, Munir (author)
- Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England.
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Limdi, Nita A. (author)
- Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA.
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- Cavallari, Larisa H. (author)
- Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA.
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- Burmester, James K. (author)
- Marshfield Clin Res Fdn, Clin Res Ctr, Marshfield, WI USA.
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- Rettie, Allan E. (author)
- Univ Washington, Sch Pharm, Dept Med Chem, Seattle, WA 98195 USA.
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- Klein, Teri E. (author)
- Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA.
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- Johnson, Julie A. (author)
- Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA.
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- Hutz, Mara H. (author)
- Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil.
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- Suarez-Kurtz, Guilherme (author)
- Inst Nacl Canc, Div Pharmacol, Rio De Janeiro, Brazil.
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Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil. (creator_code:org_t)
- Future Medicine Ltd, 2015
- 2015
- English.
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In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 16:11, s. 1253-1263
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods: Patients receiving low (<= 20 mg/week; n = 180) or high stable warfarin doses (>= 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom (R) Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes project. Results: Genome-wide signals (p <= 5 x 10(-8)) were identified in the well-known VKORC1 (lead SNP, rs749671; OR: 20.4; p = 1.08 x 10(-33)) and CYP2C9 (lead SNP, rs9332238, OR: 6.8 and p = 4.4 x 10(-13)) regions. The rs9332238 polymorphism is in virtually perfect LD with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910). No other genome-wide significant regions were identified in the study. Conclusion: We confirmed the important role of VKORC1 and CYP2C9 polymorphisms in warfarin dose.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- 1000 Genomes Project
- Brazilians
- CYP2C9
- extreme discordant phenotypes
- genome-wide association study
- VKORC1
- warfarin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Parra, Esteban J ...
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Botton, Mariana ...
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Perini, Jamila A ...
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Krithika, S.
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Bourgeois, Steph ...
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Johnson, Todd A.
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Tsunoda, Tatsuhi ...
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Pirmohamed, Muni ...
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Wadelius, Mia
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Limdi, Nita A.
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Cavallari, Laris ...
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Burmester, James ...
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Rettie, Allan E.
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Klein, Teri E.
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Johnson, Julie A ...
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Hutz, Mara H.
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Suarez-Kurtz, Gu ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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Pharmacogenomics ...
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Uppsala University