Genome-wide association study of warfarin maintenance dose in a Brazilian sample

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Genome-wide association study of warfarin maintenance dose in a Brazilian sample

Parra, Esteban J. (author): Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada.

Botton, Mariana R. (author): Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil.

Perini, Jamila A. (author): Inst Nacl Canc, Div Pharmacol, Rio De Janeiro, Brazil.

Krithika, S. (author): Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada.

Bourgeois, Stephane (author): Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.

Johnson, Todd A. (author): RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Tokyo, Japan.

Tsunoda, Tatsuhiko (author): RIKEN Ctr Integrat Med Sci, Lab Med Sci Math, Tokyo, Japan.

Pirmohamed, Munir (author): Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England.

Wadelius, Mia (author): Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab

Limdi, Nita A. (author): Univ Alabama Birmingham, Dept Neurol, Birmingham, AL 35294 USA.

Cavallari, Larisa H. (author): Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA.

Burmester, James K. (author): Marshfield Clin Res Fdn, Clin Res Ctr, Marshfield, WI USA.

Rettie, Allan E. (author): Univ Washington, Sch Pharm, Dept Med Chem, Seattle, WA 98195 USA.

Klein, Teri E. (author): Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA.

Johnson, Julie A. (author): Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL 32611 USA.

Hutz, Mara H. (author): Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil.

Suarez-Kurtz, Guilherme (author): Inst Nacl Canc, Div Pharmacol, Rio De Janeiro, Brazil.

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Univ Toronto, Dept Anthropol, Mississauga, ON L5L 1C6, Canada Univ Fed Rio Grande do Sul, Dept Genet, BR-90046900 Porto Alegre, RS, Brazil. (creator_code:org_t)

Future Medicine Ltd, 2015
2015
English.
In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 16:11, s. 1253-1263

Related links:: https://europepmc.or...; show more...; https://urn.kb.se/re...; https://doi.org/10.2...; show less...

Journal article (peer-reviewed)

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Aim: Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods: Patients receiving low (<= 20 mg/week; n = 180) or high stable warfarin doses (>= 42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom (R) Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes project. Results: Genome-wide signals (p <= 5 x 10(-8)) were identified in the well-known VKORC1 (lead SNP, rs749671; OR: 20.4; p = 1.08 x 10(-33)) and CYP2C9 (lead SNP, rs9332238, OR: 6.8 and p = 4.4 x 10(-13)) regions. The rs9332238 polymorphism is in virtually perfect LD with CYP2C9*2 (rs1799853) and CYP2C9*3 (rs1057910). No other genome-wide significant regions were identified in the study. Conclusion: We confirmed the important role of VKORC1 and CYP2C9 polymorphisms in warfarin dose.

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By the author/editor: Parra, Esteban J ...; Botton, Mariana ...; Perini, Jamila A ...; Krithika, S.; Bourgeois, Steph ...; Johnson, Todd A.; show more...; Tsunoda, Tatsuhi ...; Pirmohamed, Muni ...; Wadelius, Mia; Limdi, Nita A.; Cavallari, Laris ...; Burmester, James ...; Rettie, Allan E.; Klein, Teri E.; Johnson, Julie A ...; Hutz, Mara H.; Suarez-Kurtz, Gu ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

Articles in the publication: Pharmacogenomics ...

By the university: Uppsala University

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Genome-wide association study of warfarin maintenance dose in a Brazilian sample

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