Search: onr:"swepub:oai:DiVA.org:uu-265004" >
Quantification of [...
Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium
-
Harms, Hendrik J (author)
-
de Haan, Stefan (author)
-
Knaapen, Paul (author)
-
show more...
-
Allaart, Cornelis P (author)
-
Rijnierse, Mischa T (author)
-
Schuit, Robert C (author)
-
Windhorst, Albert D (author)
-
Lammertsma, Adriaan A (author)
-
Huisman, Marc C (author)
-
- Lubberink, Mark (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
-
show less...
-
(creator_code:org_t)
- 2014-09-26
- 2014
- English.
-
In: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 4
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://ejnmmires.sp...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: The aims of this study were to determine the optimal tracer kinetic model for [(11)C]-meta-hydroxyephedrine ([(11)C]HED) and to evaluate the performance of several simplified methods.METHODS: Thirty patients underwent dynamic 60-min [(11)C]HED scans with online arterial blood sampling. Single-tissue and both reversible and irreversible two-tissue models were fitted to the data using the metabolite-corrected arterial input function. For each model, reliable fits were defined as those yielding outcome parameters with a coefficient of variation (CoV) <25%. The optimal model was determined using Akaike and Schwarz criteria and the F-test, together with the number of reliable fits. Simulations were performed to study accuracy and precision of each model. Finally, quantitative results obtained using a population-averaged metabolite correction were evaluated, and simplified retention index (RI) and standardized uptake value (SUV) results were compared with quantitative volume of distribution (V T) data.RESULTS: The reversible two-tissue model was preferred in 75.8% of all segments, based on the Akaike information criterion. However, V T derived using the single-tissue model correlated highly with that of the two-tissue model (r (2) = 0.94, intraclass correlation coefficient (ICC) = 0.96) and showed higher precision (CoV of 24.6% and 89.2% for single- and two-tissue models, respectively, at 20% noise). In addition, the single-tissue model yielded reliable fits in 94.6% of all segments as compared with 77.1% for the reversible two-tissue model. A population-averaged metabolite correction could not be used in approximately 20% of the patients because of large biases in V T. RI and SUV can provide misleading results because of non-linear relationships with V T.CONCLUSIONS: Although the reversible two-tissue model provided the best fits, the single-tissue model was more robust and results obtained were similar. Therefore, the single-tissue model was preferred. RI showed a non-linear correlation with V T, and therefore, care has to be taken when using RI as a quantitative measure.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Harms, Hendrik J
-
de Haan, Stefan
-
Knaapen, Paul
-
Allaart, Corneli ...
-
Rijnierse, Misch ...
-
Schuit, Robert C
-
show more...
-
Windhorst, Alber ...
-
Lammertsma, Adri ...
-
Huisman, Marc C
-
Lubberink, Mark
-
show less...
- Articles in the publication
-
EJNMMI Research
- By the university
-
Uppsala University