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Timing of percutane...
Timing of percutaneous coronary intervention in patients with non-ST-elevation myocardial infarction : a SWEDEHEART study
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- Lindholm, Daniel (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, 1 tr, SE-752 37 Uppsala, Sweden
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- Alfredsson, Joakim, 1962- (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Angerås, Oskar (author)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden,Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Böhm, Felix (author)
- Karolinska Institutet
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- Calais, Fredrik, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Dept Cardiol, Fac Hlth, Orebro, Sweden
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- Koul, Sasha (author)
- Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden,Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
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- Lagerqvist, Bo (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, 1 tr, SE-752 37 Uppsala, Sweden
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- Renlund, Henrik (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, 1 tr, SE-752 37 Uppsala, Sweden
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- Sarno, Giovanna (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, 1 tr, SE-752 37 Uppsala, Sweden
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- Varenhorst, Christoph (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Dag Hammarskjölds väg 14B, 1 tr, SE-752 37 Uppsala, Sweden
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(creator_code:org_t)
- 2016-08-28
- 2017
- English.
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In: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 3:1, s. 53-60
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Abstract
Subject headings
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- AimsAlthough routine invasive management is recommended in NSTEMI patients, the optimal timing of the procedure is not defined. The aim of this study was to assess outcomes in relation to timing of PCI in NSTEMI patients.Methods and resultsThis was an observational, prospective, multicentre cohort study from the SWEDEHEART registry including all Swedish PCI centres. We included 40 494 consecutive PCI-treated patients who were admitted to any coronary care unit from 2006 to 2013. The primary outcome was all-cause death, and secondary outcomes were recurrent myocardial infarction (MI), stent thrombosis, and severe in-hospital bleeding. Outcomes were assessed within 1 year from admission in relation to pre-specified cut-offs to define early PCI: within 1, 2, or 3 days. Patients who received delayed PCI, compared with those who did not, were older, and had a higher prevalence of comorbidities (hypertension, hyperlipidaemia, diabetes, and prior stroke) but showed similar angiographic findings. Cox mixed-effects models showed a lower risk of all-cause death with early PCI across all three cut-offs: HR (95% CI) of 0.88 (0.80–0.98), 0.78 (0.71–0.86), and 0.75 (0.68–0.84), for the 1-, 2-, and 3-day cut-offs, respectively. Early PCI was associated with lower risk of recurrent MI for the 2- and 3-day cut-offs, but not for the 1-day cut-off. The reported rates of severe in-hospital bleeding were low, but tended to be higher in patients receiving delayed PCI.ConclusionIn patients undergoing PCI for NSTEMI, early invasive treatment is associated with lower risk of ischaemic outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiology
- acute coronary syndromes
- non-st-elevation myocardial infarction
- percutaneous coronary intervention
- timing
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lindholm, Daniel
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Alfredsson, Joak ...
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Angerås, Oskar
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Böhm, Felix
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Calais, Fredrik, ...
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Koul, Sasha
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show more...
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Lagerqvist, Bo
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Renlund, Henrik
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Sarno, Giovanna
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Varenhorst, Chri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Uppsala University
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Örebro University
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Linköping University
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Karolinska Institutet