Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus.

The aim of this study was to compare ongoing production of anti-C1q antibodies (anti-C1q) in peripheral blood with serum anti-C1q levels in patients with systemic lupus erythematosus (SLE), especially in patients with nephritis. Using the ELISPOT technique for the detection of IgG and IgA anti-C1q production, 21 patients with active SLE were investigated. ELISAs for IgG and IgA anti-C1q were compared with the ELISPOT results. Six of the patients were found to have proliferative nephritis (WHO grade III/IV) confirmed by renal biopsy. High numbers of IgG anti-C1q spot-forming cells (SFC), defined as > 20/10(5) plated peripheral blood mononuclear cells (PBMC), were exclusively observed in patients with proliferative nephritis (P < 0.0001). Serum levels of IgG anti-C1q were significantly increased in patients with proliferative nephritis (P = 0.039). High ongoing IgG anti-C1q production was observed in all patients with proliferative nephritis, which may be a contributory factor in the pathogenesis of this disorder. The detection of IgG anti-C1q production may be valuable in the clinical investigation of patients with suspected SLE nephritis.

Rönnelid, JohanUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM(Swepub:uu)joharonn (author)
Huang, Y H (author)
Rogberg, S (author)
Nilsson, BUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,KITM(Swepub:uu)bonils (author)
Lundberg, IKarolinska Institutet (author)
Klareskog, LKarolinska Institutet (author)
Karolinska InstitutetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

In:British Journal of Rheumatology: Oxford University Press (OUP)36, s. 32-0263-71031460-2172
In:Rheumatology: Oxford University Press (OUP)36, s. 32-1462-03241462-0332
In:British Journal of Rheumatology: Oxford University Press (OUP)36, s. 32-

By the author/editor: Gunnarsson, I; Rönnelid, Johan; Huang, Y H; Rogberg, S; Nilsson, B; Lundberg, I; show more...; Klareskog, L; show less...

Articles in the publication: British Journal ...; Rheumatology; British Journal ...

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