Tuberculosis associates with both airflow obstruction and low lung function: BOLD results

Amaral, Andre F. S.Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England. (author)

Tuberculosis associates with both airflow obstruction and low lung function : BOLD results

In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults. The study was performed in adults, aged 40 years and above, who took part in the multicentre, cross-sectional, general population-based Burden of Obstructive Lung Disease study, and had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis. The associations between a history of tuberculosis and airflow obstruction and spirometric restriction were assessed within each participating centre, and estimates combined using meta-analysis. These estimates were stratified by high- and low/middle-income countries, according to gross national income. A self-reported history of tuberculosis was associated with airflow obstruction (adjusted odds ratio 2.51, 95% CI 1.83-3.42) and spirometric restriction (adjusted odds ratio 2.13, 95% CI 1.42-3.19). A history of tuberculosis was associated with both airflow obstruction and spirometric restriction, and should be considered as a potentially important cause of obstructive disease and low lung function, particularly where tuberculosis is common.

Coton, SoniaUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England. (author)
Kato, BernetUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England. (author)
Tan, Wan C.Univ British Columbia, Heart Lung Innovat Ctr, Vancouver, BC V5Z 1M9, Canada. (author)
Studnicka, MichaelParacelsus Med Univ, Dept Pulm Med, Salzburg, Austria. (author)
Janson, ChristerUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)chrisjn (author)
Gislason, ThorarinnUniv Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland. (author)
Mannino, DavidUniv Kentucky, Div Pulm Crit Care & Sleep Med, Lexington, KY USA. (author)
Bateman, Eric D.Univ Cape Town, Dept Med, ZA-7925 Cape Town, South Africa. (author)
Buist, SoniaOregon Hlth & Sci Univ, Portland, OR 97201 USA. (author)
Burney, Peter G. J.Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England. (author)
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Resp Epidemiol Occupat Med & Publ Hlth, London SW3 6LR, England.Univ British Columbia, Heart Lung Innovat Ctr, Vancouver, BC V5Z 1M9, Canada. (creator_code:org_t)

In:European Respiratory Journal: European Respiratory Society (ERS)46:4, s. 1104-11120903-19361399-3003

By the author/editor: Amaral, Andre F. ...; Coton, Sonia; Kato, Bernet; Tan, Wan C.; Studnicka, Micha ...; Janson, Christer; show more...; Gislason, Thorar ...; Mannino, David; Bateman, Eric D.; Buist, Sonia; Burney, Peter G. ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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