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Second allogeneic s...
Second allogeneic stem cell transplant for aplastic anaemia : a retrospective study by the severe aplastic anaemia working party of the European society for blood and marrow transplantation
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- Cesaro, Simone (author)
- Azienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy.
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- de latour, Regis Peffault (author)
- Univ Paris 07, Dept Haematol, BMT, Hop St Louis, Paris, France.
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- Tridello, Gloria (author)
- Azienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy.
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- Pillon, Marta (author)
- Dipartimento Pediat, Clin Oncoematol Pediat, Padua, Italy.
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- Carlson, Kristina (author)
- Uppsala universitet,Hematologi
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- Fagioli, Franca (author)
- Regina Margherita Hosp, Paediat Haematol, Turin, Italy.
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- Jouet, Jean-Pierre (author)
- Hop Claude Huriez Serv Malad Sang, Lille, France.
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- Koh, Mickey B. C. (author)
- St George Hosp, Dept Haematol, London, England.
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- Panizzolo, Irene Sara (author)
- Azienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy.
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- Kyrcz-Krzemien, Slawomira (author)
- Med Univ Silesia, Univ Dept Haematol, Katowice, Poland.;BMT, Katowice, Poland.
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- Maertens, Johan (author)
- Univ Hosp Gasthuisberg, Dept Haematol, Leuven, Belgium.
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- Rambaldi, Alessandro (author)
- Osped Riuniti Bergamo, Div Ematol, Bergamo, Italy.
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- Strahm, Brigitte (author)
- Univ Med Ctr, Dept Paediat & Adolescent Med, Paediat Haematol & Oncol, Freiburg, Germany.
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- Blaise, Didier (author)
- Inst Paoli Calmettes, Ctr Rech Cancerol Marseille, Programme Transplantat & Therapie Cellulaire, Marseille, France.
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- Maschan, Alexei (author)
- Fed Res Ctr Paediat Haematol Oncol & Immunol, Moscow, Russia.
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- Marsh, Judith (author)
- Kings Coll London, Kings Coll Hosp, Dept Haematol Med, London, England.
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- Dufour, Carlo (author)
- Inst G Gaslini, Paediat Haematol, Genoa, Italy.
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Azienda Osped Univ Integrata, Paediat Haematol & Oncol, Verona, Italy Univ Paris 07, Dept Haematol, BMT, Hop St Louis, Paris, France. (creator_code:org_t)
- 2015-08-25
- 2015
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 171:4, s. 606-614
- Related links:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We analysed the outcome of a second allogeneic haematopoietic stem cell transplant (alloHSCT) in 162 patients reported to the European Society for Blood and Marrow Transplantation between 1998 and 2009. Donor origin was a sibling in 110 and an unrelated donor in 52 transplants, respectively. The stem cell source was bone marrow in 31% and peripheral blood in 69% of transplants. The same donor as for the first alloHSCT was used in 81% of transplants whereas a change in the choice of stem cell source was reported in 56% of patients, mainly from bone marrow to peripheral blood. Neutrophil and platelet engraftment occurred in 85% and 72% of patients, after a median time of 15 and 17days, respectively. Grade II-IV acute graft-versus-host disease (GVHD) and chronic GVHD occurred in 21% and 37% of patients, respectively. Graft failure (GF) occurred in 42 patients (26%). After a median follow-up of 3.5years, the 5-year overall survival (OS) was 60.7%. In multivariate analysis, the only factor significantly associated with a better outcome was a Karnofsky/Lansky score 80 (higher OS). We conclude that a second alloHSCT is feasible rescue option for GF in SAA, with a successful outcome in 60% of cases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- severe aplastic anaemia
- haematopoietic stem cell transplantation
- graft failure
- rescue treatment
- second allogeneic transplant
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cesaro, Simone
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de latour, Regis ...
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Tridello, Gloria
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Pillon, Marta
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Carlson, Kristin ...
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Fagioli, Franca
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Jouet, Jean-Pier ...
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Koh, Mickey B. C ...
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Panizzolo, Irene ...
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Kyrcz-Krzemien, ...
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Maertens, Johan
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Rambaldi, Alessa ...
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Strahm, Brigitte
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Blaise, Didier
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Maschan, Alexei
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Marsh, Judith
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Dufour, Carlo
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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Uppsala University