Search: onr:"swepub:oai:DiVA.org:uu-270232" >
Preparation of imid...
Preparation of imidazolylpyrimidine derivatives for treatment of glycogen synthase kinase 3 related disorders such as Alzheimer's disease.
-
Arvidsson, Per I. (author)
-
Burrows, Jeremy Nicholas (author)
-
Yngve, Ulrika (author)
-
show more...
-
Tjerneld, Erica. (author)
-
show less...
- AstraZeneca AB, Swed. ., 2010
- English.
- Related links:
-
https://urn.kb.se/re...
Abstract
Subject headings
Close
- Title compds. I [R1 = H or F; R2 and R3 independently = H or Me], and their pharmaceutically acceptable salts, are prepd. and disclosed as agents for treatment of glycogen synthase kinase 3 (GSK3) related disorders such as Alzheimer's disease. Thus, e.g., II.HCl was prepd. by reductive amination of 4-bromo-3-fluorobenzaldehyde with (S)-3-methylmorpholine followed by amination with 2-amino-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidine. Select I were evaluated for GSK3β inhibitory activity, and e.g., II·HCl demonstrated a Ki value of 30 nM. [on SciFinder(R)]
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- pyrimidine imidazolyl deriv prepn GSK3 inhibitor treatment Alzheimer disease
Publication and Content Type
- pop (subject category)
- pat (subject category)
To the university's database