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  • Burke, Michael J.Med Coll Wisconsin, Dept Pediat, Div Hematol Oncol Blood & Marrow Transplant, Milwaukee, WI 53226 USA.;Childrens Hosp Wisconsin, Milwaukee, WI 53226 USA. (author)

Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission : A Report from the Center for International Blood and Marrow Transplant Research

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-270422
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-270422URI
  • https://doi.org/10.1016/j.bbmt.2015.08.023DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132455571URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Survival for children with relapsed T cell acute lymphoblastic leukemia (T-ALL) is poor when treated with chemotherapy alone, and outcomes after allogeneic hematopoietic cell transplantation (HCT) is not well described. Two hundred twenty-nine children with T-ALL in second complete remission (CR2) received an HCT after myeloablative conditioning between 2000 and 2011 and were reported to the Center for International Blood and Marrow Transplant Research. Median age was 10 years (range, 2 to 18). Donor source was umbilical cord blood (26%), matched sibling bone marrow (38%), or unrelated bone marrow/peripheral blood (36%). Acute (grades II to IV) and chronic graft-versus-host disease occurred in, respectively, 35% (95% confidence interval [CI], 27% to 45%) and 26% (95% CI, 20% to 33%) of patients. Transplant-related mortality at day 100 and 3-year relapse rates were 13% (95% CI, 9% to 18%) and 30% (95% CI, 24% to 37%), respectively. Three-year overall survival and disease-free survival rates were 48% (95% CI, 41% to 55%) and 46% (95% CI, 39% to 52%), respectively. In multivariate analysis, patients with bone marrow relapse, with or without concurrent extramedullary relapse before HCT, were most likely to relapse (hazard ratio, 3.94; P =.005) as compared with isolated extramedullary disease. In conclusion, HCT for pediatric T-ALL in CR2 demonstrates reasonable and durable outcomes, and consideration for HCT is warranted. (c) 2015 American Society for Blood and Marrow Transplantation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Verneris, Michael R.Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA. (author)
  • Le Rademacher, JenniferMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI 53226 USA. (author)
  • He, WenshengMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA. (author)
  • Abdel-Azim, HishamUniv So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90033 USA. (author)
  • Abraham, Allistair A.Childrens Natl Med Ctr, Ctr Canc & Blood Disorders, Div Blood & Marrow Transplantat, Washington, DC 20010 USA. (author)
  • Auletta, Jeffery J.Nationwide Childrens Hosp, Div Hematol Oncol Bone Marrow Transplantat & Infe, Columbus, OH USA. (author)
  • Ayas, MouhabKing Faisal Specialist Hosp & Res Ctr, Dept Pediat Hematol Oncol, Riyadh, Saudi Arabia. (author)
  • Brown, Valerie I.Penn State Hershey Childrens Hosp, Dept Pediat, Div Pediat Oncol Hematol, Hershey, PA USA.;Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Hershey, PA 17033 USA. (author)
  • Cairo, Mitchell S.New York Med Coll, Dept Pediat, Valhalla, NY 10595 USA. (author)
  • Chan, Ka WahTexas Transplant Inst, Dept Pediat, San Antonio, TX USA. (author)
  • Diaz Perez, Miguel A.Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain. (author)
  • Dvorak, Christopher C.Univ Calif San Francisco, Dept Pediat, Med Ctr, San Francisco, CA USA. (author)
  • Egeler, R. MaartenHosp Sick Children, Dept Hematol Oncol, Toronto, ON M5G 1X8, Canada. (author)
  • Eldjerou, LamisUniv Florida, Dept Pediat, Gainesville, FL USA. (author)
  • Frangoul, HaydarVanderbilt Univ, Dept Pediat, Div Hematol Oncol, Sch Med, Nashville, TN USA. (author)
  • Guilcher, Gregory M. T.Alberta Childrens Prov Gen Hosp, Sect Paediat Oncol & Blood & Marrow Transplant, Calgary, AB, Canada. (author)
  • Hayashi, Robert J.Washington Univ, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, St Louis, MO 63110 USA. (author)
  • Ibrahim, AhmedMakassed Gen Hosp, Dept Hematol Oncol, Beiruit, Lebanon. (author)
  • Kasow, Kimberly A.Univ N Carolina, Dept Pediat, Div Hematol Oncol, Chapel Hill, NC USA. (author)
  • Leung, Wing H.St Jude Childrens Res Hosp, Div Bone Marrow Transplantat, Memphis, TN 38105 USA. (author)
  • Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Hematologi,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden(Swepub:uu)riols677 (author)
  • Pulsipher, Michael A.Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90033 USA. (author)
  • Shah, NiketaMayo Clin Arizona, Dept Pediat, Div Hematol Oncol, Phoenix, AZ USA.;Phoenix Childrens Hosp, Phoenix, AZ USA. (author)
  • Shah, Nirali N.Natl Canc Inst NIH, Pediat Oncol Branch, Ctr Canc Res, Bethesda, MD USA. (author)
  • Thiel, ElizabethMed Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA. (author)
  • Talano, Julie-AnMed Coll Wisconsin, Dept Pediat, Div Hematol Oncol Blood & Marrow Transplant, Milwaukee, WI 53226 USA.;Childrens Hosp Wisconsin, Milwaukee, WI 53226 USA. (author)
  • Kitko, Carrie L.Vanderbilt Univ, Dept Pediat, Stem Cell Transplant Program, Nashville, TN USA. (author)
  • Med Coll Wisconsin, Dept Pediat, Div Hematol Oncol Blood & Marrow Transplant, Milwaukee, WI 53226 USA.;Childrens Hosp Wisconsin, Milwaukee, WI 53226 USA.Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA. (creator_code:org_t)

Related titles

  • In:Biology of blood and marrow transplantation: Elsevier BV21:12, s. 2154-21591083-87911523-6536

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