onr:"swepub:oai:DiVA.org:uu-270455"
Search: onr:"swepub:oai:DiVA.org:uu-270455" > Changes in CSF chol...
- 1 of 1
- Previous record
- Next record
- To hitlist
Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease
-
- Karami, Azadeh (author)
- Karolinska Institutet
-
- Eyjolfsdottir, Helga (author)
- Karolinska Institutet
-
- Vijayaraghavan, Swetha (author)
- Karolinska Institutet
- show more...
- show less...
- Karolinska Institutet Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden (creator_code:org_t)
- 2015-02-09
- 2015
- English.
- In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 11:11, s. 1316-1328
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Introduction: The extensive loss of central cholinergic functions in Alzheimer's disease (AD) brain is linked to impaired nerve growth factor (NGF) signaling. The cardinal cholinergic biomarker is the acetylcholine synthesizing enzyme, choline acetyltransferase (ChAT), which has recently been found in cerebrospinal fluid (CSF). The purpose of this study was to see if EC-NGF therapy will alter CSF levels of cholinergic biomarkers, ChAT, and acetylcholinesterase. Method: Encapsulated cell implants releasing NGF (EC-NGF) were surgically implanted bilaterally in the basal forebrain of six AD patients for 12 months and cholinergic markers in CSF were analyzed. Results: Activities of both enzymes were altered after 12 months. In particular, the activity of soluble ChAT showed high correlation with cognition, CSF tau and amyloid-beta, in vivo cerebral glucose utilization and nicotinic binding sites, and morphometric and volumetric magnetic resonance imaging measures. Discussion: A clear pattern of association is demonstrated showing a proof-of-principle effect on CSF cholinergic markers, suggestive of a beneficial EC-NGF implant therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Nerve growth factor
- Choline acetyltransferase
- Acetyl cholinesterase
- tau
- Amyloid-beta
- Nicotine receptors
- PET
- MRI
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Alzheimer's & Dementia (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Karami, Azadeh
- Eyjolfsdottir, H ...
- Vijayaraghavan, ...
- Lind, Goran
- Almqvist, Per
- Kadir, Ahmadul
- show more...
- Linderoth, Bengt
- Andreasen, Niels
- Blennow, Kaj, 19 ...
- Wall, Anders
- Westman, Eric
- Ferreira, Daniel
- Wiberg, Maria Kr ...
- Wahlund, Lars-Ol ...
- Seiger, Ake
- Nordberg, Agenta
- Wahlberg, Lars
- Darreh-Taher, Ta ...
- Eriksdotter, Mar ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Alzheimer's & De ...
- By the university
- Uppsala University
- University of Gothenburg
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
