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Identification of a...
Identification of a Neuronal Receptor Controlling Anaphylaxis
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- Rogoz, Katarzyna (author)
- Uppsala universitet,Institutionen för neurovetenskap,Sensory circuits
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- Aresh, Bejan (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Freitag, Fabio Batista (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Pettersson, Hanna (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Magnúsdóttir, Elín Ingibjörg (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Larsson Ingwall, Linn (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Haddadi Andersen, Helena (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Franck, Marina Christina Mikaela (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Nagaraja, Chetan (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Kullander, Klas (author)
- Uppsala universitet,Institutionen för neurovetenskap
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- Lagerström, Malin Charlotta (author)
- Uppsala universitet,Institutionen för neurovetenskap
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 14:2, s. 370-379
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https://doi.org/10.1...
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Abstract
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- Allergic reactions can in severe cases induce a state of circulatory shock referred to as anaphylaxis. Histamine, the primary mediator of this condition, is released from immune cells, and, therefore, anaphylaxis has so far been considered an immune system disorder. However, we here show that the glutamatergic receptor mGluR7, expressed on a subpopulation of both peripheral and spinal cord neurons, controls histamine-induced communication through calcium-dependent autoinhibition with implications for anaphylaxis. Genetic ablation of mGluR7, and thus altered regulation of histamine-sensing neurons, caused an anaphylaxis-like state in mGluR7(-/-) mice, which could be reversed by antagonizing signaling between neurons and mast cells but not by antagonizing a central itch pathway. Our findings demonstrate the vital role of nervous system control by mGluR7 in anaphylaxis and open up possibilities for preventive strategies for this life-threatening condition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rogoz, Katarzyna
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Aresh, Bejan
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Freitag, Fabio B ...
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Pettersson, Hann ...
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Magnúsdóttir, El ...
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Larsson Ingwall, ...
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Haddadi Andersen ...
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Franck, Marina C ...
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Nagaraja, Chetan
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Kullander, Klas
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Lagerström, Mali ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University