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Selective cleavage of the O-6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA
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- Foldesi, A (author)
- Uppsala universitet
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- Trifonova, A (author)
- Uppsala universitet
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- Dinya, Z (author)
- Uppsala universitet
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- (creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 1999
- 1999
- English.
- In: TETRAHEDRON LETTERS. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0040-4039. ; 40:40, s. 7283-7284
- Journal article (other academic/artistic)
Abstract
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- A facile conversion of 2',3',5'-O-tri-(Bz, Tol or Ac)-N-2-(Ac or iBu)-O-6-DPC-guanosine to N-2-(Ac or iBu)guanosine has been achieved in 89-98% yield by short treatment with 90% aqueous TFA for smooth cleavage of the DPC group followed by treatment with s
Keyword
- EFFICIENT SYNTHESIS; ANALOGS; DODECARIBONUCLEOTIDE; WINDOW; BLOCKS; DNA
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- vet (subject category)
- art (subject category)
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