The solution conformation of a carbocyclic analog of the Dickerson-Drew dodecamer: Comparison with its own X-ray structure and that of the NMR structure of the native counterpart

• The NMR conformation of a carbocyclic analog of the Dickerson-Drew dodecamer [d(CGCGAAT*T*'CGCG)](2) containing 6'-alpha-Me carbocyclic thymidines (T*) has been determined and compared with that of its X-ray structure. The solution structure of the 6'-alp

Keyword

NUCLEIC-ACID FRAGMENTS; B-DNA DODECAMER; RESTRAINED MOLECULAR-DYNAMICS; 500-MHZ H-1-NMR SPECTROSCOPY; PROTON COUPLING-CONSTANTS; PSEUDOROTATIONAL EQUILIBRIUM; PENTOFURANOSE MOIETY; SUGAR CONFORMATION; KARPLUS EQUATION; C-NUCLEOSIDES

Publication and Content Type

vet (subject category)

art (subject category)