Consensus on biomarkers for neuroendocrine tumour disease

Öberg, KjellUppsala universitet,Institutionen för medicinska vetenskaper (author)

Management of neuroendocrine neoplasia represents a clinical challenge because of its late presentation, lack of treatment options, and limitations in present imaging modalities and biomarkers to guide management. Monoanalyte biomarkers have poor sensitivity, specificity, and predictive ability. A National Cancer Institute summit, held in 2007, on neuroendocrine tumours noted biomarker limitations to be a crucial unmet need in the management of neuroendocrine tumours. A multinational consensus meeting of multidisciplinary experts in neuroendocrine tumours assessed the use of current biomarkers and defined the perquisites for novel biomarkers via the Delphi method. Consensus (at > 75%) was achieved for 88 (82%) of 107 assessment questions. The panel concluded that circulating multianalyte biomarkers provide the highest sensitivity and specifi city necessary for minimum disease detection and that this type of biomarker had sufficient information to predict treatment effectiveness and prognosis. The panel also concluded that no monoanalyte biomarker of neuroendocrine tumours has yet fulfilled these criteria and there is insufficient information to support the clinical use of miRNA or circulating tumour cells as useful prognostic markers for this disease. The panel considered that trials measuring multianalytes (eg, neuroendocrine gene transcripts) should also identify how such information can optimise the management of patients with neuroendocrine tumours.

Modlin, Irvin M.Yale Univ, Sch Med, New Haven, CT 06510 USA. (author)
De Herder, WouterErasmus MC, Endocrinol Sect, Dept Internal Med, Rotterdam, Netherlands. (author)
Pavel, MarianneCharite, D-13353 Berlin, Germany. (author)
Klimstra, DavidMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. (author)
Frilling, AndreaUniv London Imperial Coll Sci Technol & Med, London, England. (author)
Metz, David C.Univ Penn Hlth Syst, Div Gastroenterol, Philadelphia, PA USA. (author)
Heaney, AnthonyUniv Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. (author)
Kwekkeboom, DikErasmus MC, Dept Nucl Med, Rotterdam, Netherlands. (author)
Strosberg, JonathanH Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA. (author)
Meyer, TimothyUCL, Inst Canc, London, England. (author)
Moss, Steven F.Brown Univ, Liver Res Ctr, Providence, RI 02912 USA. (author)
Washington, KayVanderbilt Univ, Dept Pathol, Med Ctr, Nashville, TN 37235 USA. (author)
Wolin, EdwardUniv Kentucky, Markey Canc Ctr, Lexington, KY USA. (author)
Liu, EricVanderbilt Univ, Dept Surg, Med Ctr, Nashville, TN 37235 USA. (author)
Goldenring, JamesVanderbilt Univ, Dept Cell & Dev Biol, Med Ctr, Nashville, TN 37235 USA. (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Öberg, Kjell; Modlin, Irvin M.; De Herder, Woute ...; Pavel, Marianne; Klimstra, David; Frilling, Andrea; show more...; Metz, David C.; Heaney, Anthony; Kwekkeboom, Dik; Strosberg, Jonat ...; Meyer, Timothy; Moss, Steven F.; Washington, Kay; Wolin, Edward; Liu, Eric; Goldenring, Jame ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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