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Large-scale non-tar...
Large-scale non-targeted metabolomic profiling in three human population-based studies
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- Ganna, Andrea (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Fall, Tove (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Salihovic, Samira (author)
- Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Lee, Woojoo (author)
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Broeckling, Corey D. (author)
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- Kumar, Jitender (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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Hägg, Sara (author)
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- Stenemo, Markus (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Magnusson, Patrik K.E. (author)
- Karolinska Institutet
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Prenni, Jessica E. (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Pawitan, Yudi (author)
- Karolinska Institutet
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- Ingelsson, Erik (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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(creator_code:org_t)
- 2015-11-07
- 2016
- English.
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In: Metabolomics. - : Springer Science and Business Media LLC. - 1573-3882 .- 1573-3890. ; 12
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https://doi.org/10.1...
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Abstract
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- Non-targeted metabolomic profiling is used to simultaneously assess a large part of the metabolome in a biological sample. Here, we describe both the analytical and computational methods used to analyze a large UPLC–Q-TOF MS-based metabolomic profiling effort using plasma and serum samples from participants in three Swedish population-based studies of middle-aged and older human subjects: TwinGene, ULSAM and PIVUS. At present, more than 200 metabolites have been manually annotated in more than 3600 participants using an in-house library of standards and publically available spectral databases. Data available at the metabolights repository include individual raw unprocessed data, processed data, basic demographic variables and spectra of annotated metabolites. Additional phenotypical and genetic data is available upon request to cohort steering committees. These studies represent a unique resource to explore and evaluate how metabolic variability across individuals affects human diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Metabolomics Epidemiology Annotation
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ganna, Andrea
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Fall, Tove
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Salihovic, Samir ...
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Lee, Woojoo
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Broeckling, Core ...
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Kumar, Jitender
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show more...
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Hägg, Sara
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Stenemo, Markus
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Magnusson, Patri ...
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Prenni, Jessica ...
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Lind, Lars
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Pawitan, Yudi
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Ingelsson, Erik
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Metabolomics
- By the university
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Uppsala University
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Karolinska Institutet